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Bactericidal/Permeability Increasing Protein (BPI)

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CAP 57

Bactericidal/Permeability Increasing Protein (BPI)
CCC B234
HGNC 1095
MGI 3045315
PubMed 9665269
RGD 1303179
UniProt P17213
Wiki BPI

BPI was initially identified in neutrophils, but is found in other tissues including the epithelial lining of mucus membranes. It is an endogenous antibiotic protein with potent killing activity against some bacteria (Gram-negative bacteria). It binds to compounds called lipopolysaccharides produced by Gram-negative bacteria. Lipolysaccharides are potent activators of the immune system, however BPI at certain concentrations can prevent this activation.

Because lipopolysaccharides are potent inflammatory agents, and the action of antibiotics can result in the release of these compounds, the binding capacity of BPI was explored as a possible means of reducing injury. Xoma Ltd. developed a recombinant 25kDa portion of the BPI molecule called rBPI21, NEUPREX or opebecan.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB234Hu01 Recombinant Bactericidal/Permeability Increasing Protein (BPI) Positive Control; Immunogen; SDS-PAGE; WB.
RPB234Hu02 Recombinant Bactericidal/Permeability Increasing Protein (BPI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB234Hu01 Polyclonal Antibody to Bactericidal/Permeability Increasing Protein (BPI) WB; IHC; ICC; IP.
MAB234Hu22 Monoclonal Antibody to Bactericidal/Permeability Increasing Protein (BPI) WB; IHC; ICC; IP.
PAB234Hu02 Polyclonal Antibody to Bactericidal/Permeability Increasing Protein (BPI) WB; IHC; ICC; IP.
Assay Kits SEB234Hu ELISA Kit for Bactericidal/Permeability Increasing Protein (BPI) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB234Mu01 Recombinant Bactericidal/Permeability Increasing Protein (BPI) Positive Control; Immunogen; SDS-PAGE; WB.
RPB234Mu02 Recombinant Bactericidal/Permeability Increasing Protein (BPI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB234Mu01 Polyclonal Antibody to Bactericidal/Permeability Increasing Protein (BPI) WB; IHC; ICC; IP.
PAB234Mu02 Polyclonal Antibody to Bactericidal/Permeability Increasing Protein (BPI) WB; IHC; ICC; IP.
Assay Kits SEB234Mu ELISA Kit for Bactericidal/Permeability Increasing Protein (BPI) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB234Ra01 Recombinant Bactericidal/Permeability Increasing Protein (BPI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB234Ra01 Polyclonal Antibody to Bactericidal/Permeability Increasing Protein (BPI) WB; IHC; ICC; IP.
LAB234Ra71 Biotin-Linked Polyclonal Antibody to Bactericidal/Permeability Increasing Protein (BPI) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Bactericidal/Permeability Increasing Protein (BPI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bactericidal/Permeability Increasing Protein (BPI) ELISA Kit Customized Service Offer

Organism species: Oryctolagus cuniculus (Rabbit)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB234Rb01 Recombinant Bactericidal/Permeability Increasing Protein (BPI) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB234Rb51 Polyclonal Antibody to Bactericidal/Permeability Increasing Protein (BPI) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Bactericidal/Permeability Increasing Protein (BPI) CLIA Kit Customized Service Offer
n/a ELISA Kit for Bactericidal/Permeability Increasing Protein (BPI) ELISA Kit Customized Service Offer
  1. "Cloning of the cDNA of a human neutrophil bactericidal protein. Structural and functional correlations."J. Biol. Chem. 264:9505-9509(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation."J. Biol. Chem. 269:17411-17416(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Comparison of granule proteins from human polymorphonuclear leukocytes which are bactericidal toward Pseudomonas aeruginosa."Infect. Immun. 59:4193-4200(1991) [PubMed] [Europe PMC] [Abstract]
  7. "Antibiotic proteins of human polymorphonuclear leukocytes."Proc. Natl. Acad. Sci. U.S.A. 86:5610-5614(1989) [PubMed] [Europe PMC] [Abstract]
  8. "A 25-kDa NH2-terminal fragment carries all the antibacterial activities of the human neutrophil 60-kDa bactericidal/permeability-increasing protein."J. Biol. Chem. 262:14891-14894(1987) [PubMed] [Europe PMC] [Abstract]
  9. "Expression and characterization of cysteine-modified variants of an amino-terminal fragment of bactericidal/permeability-increasing protein."Protein Expr. Purif. 8:28-40(1996) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of human BPI and two bound phospholipids at 2.4-A resolution."Science 276:1861-1864(1997) [PubMed] [Europe PMC] [Abstract]
  11. "The 1.7 A crystal structure of BPI: a study of how two dissimilar amino acid sequences can adopt the same fold."J. Mol. Biol. 299:1019-1034(2000) [PubMed] [Europe PMC] [Abstract]