Tumor Necrosis Factor Receptor Superfamily, Member 5 (TNFRSF5)

[Edit]

CD40; CDW40; Bp50; P50; B-cell surface antigen CD40; CD40L receptor

Tumor Necrosis Factor Receptor Superfamily, Member 5 (TNFRSF5)
CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB249Hu01Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 5 (TNFRSF5)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB249Hu01Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 5 (TNFRSF5)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 5 (TNFRSF5)CLIA Kit Customized Service Offer
n/aELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 5 (TNFRSF5)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB249Mu01Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 5 (TNFRSF5)SDS-PAGE; WB; ELISA; IP.
RPB249Mu02Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 5 (TNFRSF5)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB249Mu01Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 5 (TNFRSF5)WB, ICC, IHC-P, IHC-F, ELISA
PAB249Mu02Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 5 (TNFRSF5)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEB249MuELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 5 (TNFRSF5)Enzyme-linked immunosorbent assay

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB249Ra01Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 5 (TNFRSF5)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB249Ra01Polyclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 5 (TNFRSF5)WB, ICC, IHC-P, IHC-F, ELISA
MAB249Ra21Monoclonal Antibody to Tumor Necrosis Factor Receptor Superfamily, Member 5 (TNFRSF5)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEB249RaELISA Kit for Tumor Necrosis Factor Receptor Superfamily, Member 5 (TNFRSF5)Enzyme-linked immunosorbent assay
  1. "A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas."EMBO J. 8:1403-1410(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Regulation of CD40 function by its isoforms generated through alternative splicing."Proc. Natl. Acad. Sci. U.S.A. 98:1751-1756(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Biochemical characteristics and partial amino acid sequence of the receptor-like human B cell and carcinoma antigen CDw40."J. Immunol. 142:562-567(1989) [PubMed] [Europe PMC] [Abstract]
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Determination of carbohydrate structures N-linked to soluble CD154 and characterization of the interactions of CD40 with CD154 expressed in Pichia pastoris and Chinese hamster ovary cells."Protein Expr. Purif. 23:301-310(2001) [PubMed] [Europe PMC] [Abstract]
  8. "A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40."FEBS Lett. 358:113-118(1995) [PubMed] [Europe PMC] [Abstract]
  9. "Involvement of CRAF1, a relative of TRAF, in CD40 signaling."Science 267:1494-1498(1995) [PubMed] [Europe PMC] [Abstract]
  10. "CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization."Biochemistry 37:11836-11845(1998) [PubMed] [Europe PMC] [Abstract]
  11. "Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5)."Gene 207:135-140(1998) [PubMed] [Europe PMC] [Abstract]
  12. "Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway."J. Exp. Med. 187:237-244(1998) [PubMed] [Europe PMC] [Abstract]
  13. "Construction and analysis of a detailed three-dimensional model of the ligand binding domain of the human B cell receptor CD40."Proteins 27:59-70(1997) [PubMed] [Europe PMC] [Abstract]
  14. "The role of polar interactions in the molecular recognition of CD40L with its receptor CD40."Protein Sci. 7:1124-1135(1998) [PubMed] [Europe PMC] [Abstract]
  15. "Molecular basis for CD40 signaling mediated by TRAF3."Proc. Natl. Acad. Sci. U.S.A. 97:10395-10399(2000) [PubMed] [Europe PMC] [Abstract]
  16. "Downstream regulator TANK binds to the CD40 recognition site on TRAF3."Structure 10:403-411(2002) [PubMed] [Europe PMC] [Abstract]
  17. "Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM."Proc. Natl. Acad. Sci. U.S.A. 98:12614-12619(2001) [PubMed] [Europe PMC] [Abstract]