Presenilin 2 (PS2)

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PSEN2; AD3L; AD4; PS2; STM2; AD3LP; AD5; Alzheimer Disease 4

Presenilin 2 (PS2)
Presenilin-2is a protein that is encoded by the PSEN2 gene. Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified. In melanocytic cells PSEN2 gene expression may be regulated by MITF.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Presenilin 2 (PS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Presenilin 2 (PS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Presenilin 2 (PS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Presenilin 2 (PS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Presenilin 2 (PS2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Presenilin 2 (PS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Presenilin 2 (PS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Presenilin 2 (PS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Presenilin 2 (PS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Presenilin 2 (PS2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB274Ra01 Recombinant Presenilin 2 (PS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB274Ra01 Polyclonal Antibody to Presenilin 2 (PS2) WB; IHC; ICC; IP.
MAB274Ra21 Monoclonal Antibody to Presenilin 2 (PS2) WB; IHC; ICC; IP.
Assay Kits SEB274Ra ELISA Kit for Presenilin 2 (PS2) Enzyme-linked immunosorbent assay for Antigen Detection.
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