Presenilin 2 (PS2)

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PSEN2; AD3L; AD4; PS2; STM2; AD3LP; AD5; Alzheimer Disease 4

Presenilin 2 (PS2)
Presenilin-2is a protein that is encoded by the PSEN2 gene. Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified. In melanocytic cells PSEN2 gene expression may be regulated by MITF.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Presenilin 2 (PS2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Presenilin 2 (PS2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Presenilin 2 (PS2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Presenilin 2 (PS2)CLIA Kit Customized Service Offer
n/aELISA Kit for Presenilin 2 (PS2)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Presenilin 2 (PS2)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Presenilin 2 (PS2)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Presenilin 2 (PS2)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Presenilin 2 (PS2)CLIA Kit Customized Service Offer
n/aELISA Kit for Presenilin 2 (PS2)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB274Ra01Recombinant Presenilin 2 (PS2)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB274Ra01Polyclonal Antibody to Presenilin 2 (PS2)WB, ICC, IHC-P, IHC-F, ELISA
MAB274Ra21Monoclonal Antibody to Presenilin 2 (PS2)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEB274RaELISA Kit for Presenilin 2 (PS2)Enzyme-linked immunosorbent assay for Antigen Detection
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