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Complement C4-B (C4B)

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CO4; CPAMD3; Basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3; Complement component 4B, Chido blood group

Complement C4-B (C4B)
CCC B305
HGNC 1324
MGI 88228
PubMed 28205620
RGD 1605129
UniProt P0C0L5
Wiki C4B

Complement component 4B (Chido blood group) is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB305Hu01 Recombinant Complement C4-B (C4B) Positive Control; Immunogen; SDS-PAGE; WB.
RPB305Hu02 Recombinant Complement C4-B (C4B) Positive Control; Immunogen; SDS-PAGE; WB.
RPB305Hu03 Recombinant Complement C4-B (C4B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB305Hu01 Polyclonal Antibody to Complement C4-B (C4B) WB,IHC
MAB305Hu22 Monoclonal Antibody to Complement C4-B (C4B) WB; IHC; ICC; IP.
PAB305Hu02 Polyclonal Antibody to Complement C4-B (C4B) WB,IHC
PAB305Hu03 Polyclonal Antibody to Complement C4-B (C4B) WB; IHC; ICC; IP.
MAB305Hu21 Monoclonal Antibody to Complement C4-B (C4B) WB; IHC; ICC; IP.
MAB305Hu23 Monoclonal Antibody to Complement C4-B (C4B) WB; IHC; ICC; IP.
Assay Kits SEB305Hu ELISA Kit for Complement C4-B (C4B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB305Mu01 Recombinant Complement C4-B (C4B) Positive Control; Immunogen; SDS-PAGE; WB.
RPB305Mu02 Recombinant Complement C4-B (C4B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB305Mu01 Polyclonal Antibody to Complement C4-B (C4B) WB; IHC
LAB305Mu71 Biotin-Linked Polyclonal Antibody to Complement C4-B (C4B) WB; IHC; ICC.
LAB305Mu81 FITC-Linked Polyclonal Antibody to Complement C4-B (C4B) WB; IHC; ICC; IF.
PAB305Mu02 Polyclonal Antibody to Complement C4-B (C4B) WB; IHC; ICC; IP.
Assay Kits SEB305Mu ELISA Kit for Complement C4-B (C4B) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB305Ra01 Recombinant Complement C4-B (C4B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Complement C4-B (C4B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Complement C4-B (C4B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Complement C4-B (C4B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Complement C4-B (C4B) ELISA Kit Customized Service Offer
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  2. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
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  4. "Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein."FEBS Lett. 271:131-136(1990) [PubMed] [Europe PMC] [Abstract]
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  6. "Amino acid sequence around the thiol and reactive acyl groups of human complement component C4."Biochem. J. 199:359-370(1981) [PubMed] [Europe PMC] [Abstract]
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  8. "Sequence determination of the thiolester site of the fourth component of human complement."Proc. Natl. Acad. Sci. U.S.A. 78:7388-7392(1981) [PubMed] [Europe PMC] [Abstract]
  9. "C4d DNA sequences of two infrequent human allotypes (C4A13 and C4B12) and the presence of signal sequences enhancing recombination."J. Immunol. 161:3438-3443(1998) [PubMed] [Europe PMC] [Abstract]
  10. "C4d DNA sequence of complement C4B93 and recombination mechanisms for its generation."Tissue Antigens 63:260-262(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4."FEBS Lett. 154:387-390(1983) [PubMed] [Europe PMC] [Abstract]
  12. "Identification of the site of sulfation of the fourth component of human complement."J. Biol. Chem. 261:1786-1793(1986) [PubMed] [Europe PMC] [Abstract]
  13. "Complete C4B deficiency in black Americans with systemic lupus erythematosus."J. Rheumatol. 15:1855-1858(1988) [PubMed] [Europe PMC] [Abstract]
  14. "Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A."Proc. Natl. Acad. Sci. U.S.A. 87:6868-6872(1990) [PubMed] [Europe PMC] [Abstract]
  15. "The reaction mechanism of the internal thioester in the human complement component C4."Nature 379:177-179(1996) [PubMed] [Europe PMC] [Abstract]
  16. "Deficiency of human complement protein C4 due to identical frameshift mutations in the C4A and C4B genes."J. Immunol. 162:3687-3693(1999) [PubMed] [Europe PMC] [Abstract]
  17. "Genetic, structural and functional diversities of human complement components C4A and C4B and their mouse homologues, Slp and C4."Int. Immunopharmacol. 1:365-392(2001) [PubMed] [Europe PMC] [Abstract]
  18. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
  20. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
  21. "Structural basis of the polymorphism of human complement components C4A and C4B: gene size, reactivity and antigenicity."EMBO J. 5:2873-2881(1986) [PubMed] [Europe PMC] [Abstract]
  22. "Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans." Am. J. Hum. Genet. 80:1037-1054(2007) [PubMed] [Europe PMC] [Abstract]