Perforin 1 (PRF1)

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FLH2; HPLH2; P1; PFP; Pore Forming Protein; Cytolysin; Lymphocyte pore-forming protein

Perforin 1 (PRF1)
Perforin is a cytolytic protein found in the granules of CD8 T-cells and NK cells. Perforin is a cytolytic protein found in the granules of Cytotoxic T lymphocytes (CTLs) and NK cells. Upon degranulation, perforin inserts itself into the target cell's plasma membrane, forming a pore. The lytic membrane-inserting part of perforin is the MACPF domain. This region shares homology with cholesterol-dependent cytolysins from Gram-positive bacteria. Perforin has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB317Hu01Recombinant Perforin 1 (PRF1)SDS-PAGE; WB; ELISA; IP; CoIP; Reporter Assays; Purification; Amine Reactive Labeling.
AntibodiesPAB317Hu01Polyclonal Antibody to Perforin 1 (PRF1)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
MAB317Hu22Monoclonal Antibody to Perforin 1 (PRF1)WB, ICC, IHC-P, IHC-F, ELISA
LAB317Hu81FITC-Linked Polyclonal Antibody to Perforin 1 (PRF1)IHC;ICC;IF;WB
LAB317Hu71Biotin-Linked Polyclonal Antibody to Perforin 1 (PRF1)IHC;WB;ELISA
Assay KitsSEB317HuELISA Kit for Perforin 1 (PRF1)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB317Mu01Recombinant Perforin 1 (PRF1)SDS-PAGE; WB; ELISA; IP; CoIP; ReporterAssays; Purification; Amine Reactive Labeling.
RPB317Mu02Recombinant Perforin 1 (PRF1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB317Mu01Polyclonal Antibody to Perforin 1 (PRF1)WB, ICC, IHC-P, IHC-F, ELISA
LAB317Mu81FITC-Linked Polyclonal Antibody to Perforin 1 (PRF1)IHC;ICC;IF;WB
LAB317Mu71Biotin-Linked Polyclonal Antibody to Perforin 1 (PRF1)IHC;WB;ELISA
PAB317Mu02Polyclonal Antibody to Perforin 1 (PRF1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEB317MuELISA Kit for Perforin 1 (PRF1)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB317Ra01Recombinant Perforin 1 (PRF1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB317Ra01Polyclonal Antibody to Perforin 1 (PRF1)WB, ICC, IHC-P, IHC-F, ELISA
MAB317Ra21Monoclonal Antibody to Perforin 1 (PRF1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEB317RaELISA Kit for Perforin 1 (PRF1)Enzyme-linked immunosorbent assay for Antigen Detection
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  10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
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  14. "Localization and molecular modelling of the membrane-inserted domain of the ninth component of human complement and perforin."Mol. Immunol. 27:589-602(1990) [PubMed] [Europe PMC] [Abstract]
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  18. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]