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B-Lymphocyte Activation Antigen B7-1 (LAB7-1)

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CD80; CD28LG; CD28LG1; BB1; B7-1 Antigen; T-lymphocyte activation antigen CD80; CTLA-4 counter-receptor B7.1

B-Lymphocyte Activation Antigen B7-1 (LAB7-1)
CCC B386
HGNC 1700
MGI 101775
PubMed 12015893
RGD 2314
UniProt P33681
Wiki CD80

The protein CD80 is a molecule found on activated B cells and monocytes which provides a costimulatory signal necessary for T cell activation and survival. It is also known as B7.1. Its principal mode of action is by binding to CD28. Along with CD86, these molecules provide the necessary stimuli to prime T cells against antigens presented by antigen-presenting cells. CD80 and CD86 also bind to CTLA-4, a cell surface molecule expressed on activated T cells. Interactions between CD80 or CD86 with CTLA-4 decrease the response of T cells.  

Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. Acts as a receptor for adenovirus subgroup B.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins EPB386Hu61 Eukaryotic B-Lymphocyte Activation Antigen B7-1 (LAB7-1) Positive Control; Immunogen; SDS-PAGE; WB.
APB386Hu61 Active B-Lymphocyte Activation Antigen B7-1 (LAB7-1) Cell culture; Activity Assays.
Antibodies PAB386Hu01 Polyclonal Antibody to B-Lymphocyte Activation Antigen B7-1 (LAB7-1) WB; IHC; ICC; IP.
PAB386Hu06 Polyclonal Antibody to B-Lymphocyte Activation Antigen B7-1 (LAB7-1) WB; IHC; ICC; IP.
Assay Kits SEB386Hu ELISA Kit for B-Lymphocyte Activation Antigen B7-1 (LAB7-1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB386Mu01 Recombinant B-Lymphocyte Activation Antigen B7-1 (LAB7-1) Positive Control; Immunogen; SDS-PAGE; WB.
APB386Mu01 Active B-Lymphocyte Activation Antigen B7-1 (LAB7-1) Cell culture; Activity Assays.
Antibodies PAB386Mu01 Polyclonal Antibody to B-Lymphocyte Activation Antigen B7-1 (LAB7-1) WB; IHC; ICC; IP.
Assay Kits SEB386Mu ELISA Kit for B-Lymphocyte Activation Antigen B7-1 (LAB7-1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB386Ra01 Recombinant B-Lymphocyte Activation Antigen B7-1 (LAB7-1) Positive Control; Immunogen; SDS-PAGE; WB.
APB386Ra01 Active B-Lymphocyte Activation Antigen B7-1 (LAB7-1) Cell culture; Activity Assays.
Antibodies n/a Monoclonal Antibody to B-Lymphocyte Activation Antigen B7-1 (LAB7-1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to B-Lymphocyte Activation Antigen B7-1 (LAB7-1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for B-Lymphocyte Activation Antigen B7-1 (LAB7-1) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Lymphocyte Activation Antigen B7-1 (LAB7-1) ELISA Kit Customized Service Offer
  1. "B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells."J. Immunol. 143:2714-2722(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7."Immunogenetics 36:175-181(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Human Soluble CD80 is generated by alternative splicing, and recombinant soluble CD80 binds to CD28 and CD152 influencing T-cell activation."Scand. J. Immunol. 66:529-537(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7."J. Exp. Med. 174:625-631(1991) [PubMed] [Europe PMC] [Abstract]
  7. "CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL."J. Immunol. 154:97-105(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Interaction of CTLA-4 (CD152) with CD80 or CD86 inhibits human T-cell activation."Immunology 98:413-421(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors."Virus Res. 122:144-153(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Structure and dimerization of a soluble form of B7-1."Immunity 12:51-60(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses."Nature 410:608-611(2001) [PubMed] [Europe PMC] [Abstract]