Interleukin 1 Receptor Associated Kinase 4 (IRAK4)

IRAK-4 is a protein kinase involved in signaling innate immune responses from Toll-like receptors. It also supports signaling from T-cell receptors.Animals without IRAK-4 are more susceptible to viruses and bacteria but completely resistant to LPS challenge.Unlike the other IRAK proteins, however, but similar to Pelle, IRAK4 has a short C-terminal domain. Northern blot analysis revealed expression of 3.0- and 4.4-kb transcripts, with strongest expression in kidney and liver. Luciferase reporter analysis showed that IRAK4 lacking the kinase domain inhibited IL1- but not tumor necrosis factor (TNF)- induced NFKB and IRAK1 activation. SDS-PAGE and autoradiographic analysis indicated that IRAK4 phosphorylates and activates IRAK1 at thr387, but not vice versa.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB518Hu01 Recombinant Interleukin 1 Receptor Associated Kinase 4 (IRAK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB518Hu01 Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) WB; ICC; IHC-P; IHC-F; ELISA.
MAB518Hu22 Monoclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) WB; IHC; ICC; IP.
Assay Kits SEB518Hu ELISA Kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interleukin 1 Receptor Associated Kinase 4 (IRAK4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB518Ra01 Recombinant Interleukin 1 Receptor Associated Kinase 4 (IRAK4) Positive Control; Immunogen; SDS-PAGE; WB.
RPB518Ra02 Recombinant Interleukin 1 Receptor Associated Kinase 4 (IRAK4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB518Ra01 Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) WB; IHC; ICC; IP.
MAB518Ra21 Monoclonal Antibody to Interleukin 1 Receptor Associated Kinase 4 (IRAK4) WB; IHC; ICC; IP.
Assay Kits SEB518Ra ELISA Kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) Enzyme-linked immunosorbent assay for Antigen Detection.
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  28. "Crystal structures of the apo and inhibited IRAK4 kinase domain."Submitted (DEC-2006) to the PDB data bank
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  35. "Functional assessment of the mutational effects of human IRAK4 and MyD88 genes."Mol. Immunol. 58:66-76(2014) [PubMed] [Europe PMC] [Abstract]