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Cluster Of Differentiation 147 (CD147)

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EMMPRIN; BSG; 5F7; M6; OK; TCSF; Basigin(Ok Blood Group); Collagenase stimulatory factor; OK blood group antigen; Tumor cell-derived collagenase stimulatory factor

Cluster Of Differentiation 147 (CD147)
CCC B540
HGNC 1116
MGI 88208
PubMed 10706100
RGD 2220
UniProt P35613
Wiki Basigin

Basigin is a member of the immunoglobulin superfamily, with a structure related to the putative primordial form of the family. As members of the immunoglobulin superfamily play fundamental roles in intercellular recognition involved in various immunologic phenomena, differentiation, and development, basigin is thought also to play a role in intercellular recognition.It has a variety of functions. In addition to its metalloproteinase-inducing ability, basigin also regulates several distinct functions, such as spermatogenesis, expression of the monocarboxylate transporter and the responsiveness of lymphocytes.Basigin is a type I integral membrane receptor that has many ligands, including the cyclophilin  proteins Cyp-A and CyP-B and certain integrins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB540Hu01 Recombinant Cluster Of Differentiation 147 (CD147) Positive Control; Immunogen; SDS-PAGE; WB.
EPB540Hu61 Eukaryotic Cluster Of Differentiation 147 (CD147) Positive Control; Immunogen; SDS-PAGE; WB.
RPB540Hu02 Recombinant Cluster Of Differentiation 147 (CD147) Positive Control; Immunogen; SDS-PAGE; WB.
APB540Hu61 Active Cluster Of Differentiation 147 (CD147) Cell culture; Activity Assays.
APB540Hu01 Active Cluster Of Differentiation 147 (CD147) Cell culture; Activity Assays.
APB540Hu02 Active Cluster Of Differentiation 147 (CD147) Cell culture; Activity Assays.
Antibodies PAB540Hu01 Polyclonal Antibody to Cluster Of Differentiation 147 (CD147) WB; IHC; ICC; IP.
MAB540Hu22 Monoclonal Antibody to Cluster Of Differentiation 147 (CD147) WB; IHC; ICC; IP.
MAB540Hu21 Monoclonal Antibody to Cluster Of Differentiation 147 (CD147) WB; IHC; ICC; IP.
MAB540Hu23 Monoclonal Antibody to Cluster Of Differentiation 147 (CD147) WB; IHC; ICC; IP.
MAB540Hu27 Monoclonal Antibody to Cluster Of Differentiation 147 (CD147) WB; IHC; ICC; IP.
MAB540Hu24 Monoclonal Antibody to Cluster Of Differentiation 147 (CD147) WB; IHC; ICC; IP.
MAB540Hu25 Monoclonal Antibody to Cluster Of Differentiation 147 (CD147) WB; IHC; ICC; IP.
MAB540Hu28 Monoclonal Antibody to Cluster Of Differentiation 147 (CD147) WB; IHC; ICC; IP.
MAB540Hu29 Monoclonal Antibody to Cluster Of Differentiation 147 (CD147) WB; IHC; ICC; IP.
Assay Kits SEB540Hu ELISA Kit for Cluster Of Differentiation 147 (CD147) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB540Mu01 Recombinant Cluster Of Differentiation 147 (CD147) Positive Control; Immunogen; SDS-PAGE; WB.
EPB540Mu61 Eukaryotic Cluster Of Differentiation 147 (CD147) Positive Control; Immunogen; SDS-PAGE; WB.
RPB540Mu02 Recombinant Cluster Of Differentiation 147 (CD147) Positive Control; Immunogen; SDS-PAGE; WB.
APB540Mu61 Active Cluster Of Differentiation 147 (CD147) Cell culture; Activity Assays.
APB540Mu01 Active Cluster Of Differentiation 147 (CD147) Cell culture; Activity Assays.
APB540Mu02 Active Cluster Of Differentiation 147 (CD147) Cell culture; Activity Assays.
Antibodies PAB540Mu01 Polyclonal Antibody to Cluster Of Differentiation 147 (CD147) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cluster Of Differentiation 147 (CD147) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cluster Of Differentiation 147 (CD147) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB540Ra01 Recombinant Cluster Of Differentiation 147 (CD147) Positive Control; Immunogen; SDS-PAGE; WB.
EPB540Ra61 Eukaryotic Cluster Of Differentiation 147 (CD147) Positive Control; Immunogen; SDS-PAGE; WB.
RPB540Ra02 Recombinant Cluster Of Differentiation 147 (CD147) Positive Control; Immunogen; SDS-PAGE; WB.
APB540Ra61 Active Cluster Of Differentiation 147 (CD147) Cell culture; Activity Assays.
APB540Ra01 Active Cluster Of Differentiation 147 (CD147) Cell culture; Activity Assays.
APB540Ra02 Active Cluster Of Differentiation 147 (CD147) Cell culture; Activity Assays.
Antibodies PAB540Ra01 Polyclonal Antibody to Cluster Of Differentiation 147 (CD147) WB; IHC; ICC; IP.
MAB540Ra21 Monoclonal Antibody to Cluster Of Differentiation 147 (CD147) WB; IHC; ICC; IP.
Assay Kits SEB540Ra ELISA Kit for Cluster Of Differentiation 147 (CD147) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule."J. Immunol. 149:847-854(1992) [PubMed] [Europe PMC] [Abstract]
  2. "The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen."J. Biochem. 110:770-774(1991) [PubMed] [Europe PMC] [Abstract]
  3. "The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily."Cancer Res. 55:434-439(1995) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases."Gene 220:99-108(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily."Invest. Ophthalmol. Vis. Sci. 44:4086-4096(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of basigin isoforms and the inhibitory function of basigin-3 in human hepatocellular carcinoma proliferation and invasion."Mol. Cell. Biol. 31:2591-2604(2011) [PubMed] [Europe PMC] [Abstract]
  7. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Partial sequencing and characterization of the tumor cell-derived collagenase stimulatory factor."Arch. Biochem. Biophys. 285:90-96(1991) [PubMed] [Europe PMC] [Abstract]
  12. "Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion."Histol. Histopathol. 18:981-987(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60."J. Biol. Chem. 280:27866-27871(2005) [PubMed] [Europe PMC] [Abstract]
  15. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
  17. "The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity."Mol. Membr. Biol. 23:486-498(2006) [PubMed] [Europe PMC] [Abstract]
  18. "junction protein shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147."Mol. Biol. Cell 18:1272-1281(2007) [PubMed] [Europe PMC] [Abstract]
  19. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  24. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  25. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  26. "Crystal structure of HAb18G/CD147: implications for immunoglobulin superfamily homophilic adhesion."J. Biol. Chem. 283:18056-18065(2008) [PubMed] [Europe PMC] [Abstract]
  27. "Structure of the EMMPRIN N-terminal domain 1: dimerization via beta-strand swapping."Proteins 77:1009-1014(2009) [PubMed] [Europe PMC] [Abstract]
  28. "The Ok(a) blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX-47 antigen, basigin and neurothelin, an immunoglobulin superfamily molecule that is widely expressed in human cells and tissues."Eur. J. Immunol. 27:891-897(1997) [PubMed] [Europe PMC] [Abstract]