Indoleamine-2,3-Dioxygenase (IDO)

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CD107B; INDO; Indoleamine-Pyrrole 2,3 Dioxygenase

Indoleamine-2,3-Dioxygenase (IDO)

Indoleamine 2,3-dioxygenase (IDO) is an IFN-gamma inducible 42 kDa enzyme that catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine. The gene encoding human IDO maps to chromosome 8p12-p11.

IDO, also known as INDO, is an important modulator of immunological responses and protects allogeneic concepti from alloreactive maternal lymphocytes. IDO mediates an interesting inhibitory effect of HeLa cells co-cultured with human PBLs. The ILN-2-induced proliferation response of PBLs is diminished in the presence of HeLa cells while an IDO inhbitor negates this effect. Flow cytometric analysis indicates both mature and immautre CD123-positive dentritic cells suppress T cell activity using IDO.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB547Hu01Recombinant Indoleamine-2,3-Dioxygenase (IDO)SDS-PAGE; WB; ELISA; IP; CoIP; Reporter Assays; Purification; Amine Reactive Labeling.
AntibodiesPAB547Hu01Polyclonal Antibody to Indoleamine-2,3-Dioxygenase (IDO)WB, ICC, IHC-P, IHC-F, ELISA
MAB547Hu22Monoclonal Antibody to Indoleamine-2,3-Dioxygenase (IDO)WB, ICC, IHC-P, IHC-F, ELISA
LAB547Hu71Biotin-Linked Polyclonal Antibody to Indoleamine-2,3-Dioxygenase (IDO)IHC;WB;ELISA
LAB547Hu81FITC-Linked Polyclonal Antibody to Indoleamine-2,3-Dioxygenase (IDO)IHC;ICC;IF;WB
Assay KitsSEB547HuELISA Kit for Indoleamine-2,3-Dioxygenase (IDO)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB547Mu01Recombinant Indoleamine-2,3-Dioxygenase (IDO)SDS-PAGE; WB; ELISA; IP.
RPB547Mu02Recombinant Indoleamine-2,3-Dioxygenase (IDO)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB547Mu01Polyclonal Antibody to Indoleamine-2,3-Dioxygenase (IDO)WB, ICC, IHC-P, IHC-F, ELISA
PAB547Mu02Polyclonal Antibody to Indoleamine-2,3-Dioxygenase (IDO)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEB547MuELISA Kit for Indoleamine-2,3-Dioxygenase (IDO)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB547Ra01Recombinant Indoleamine-2,3-Dioxygenase (IDO)SDS-PAGE; WB; ELISA; IP.
RPB547Ra02Recombinant Indoleamine-2,3-Dioxygenase (IDO)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB547Ra01Polyclonal Antibody to Indoleamine-2,3-Dioxygenase (IDO)WB, ICC, IHC-P, IHC-F, ELISA
LAB547Ra71Biotin-Linked Polyclonal Antibody to Indoleamine-2,3-Dioxygenase (IDO)IHC;WB;ELISA
MAB547Ra21Monoclonal Antibody to Indoleamine-2,3-Dioxygenase (IDO)WB, ICC, IHC-P, IHC-F, ELISA
PAB547Ra02Polyclonal Antibody to Indoleamine-2,3-Dioxygenase (IDO)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEB547RaELISA Kit for Indoleamine-2,3-Dioxygenase (IDO)Enzyme-linked immunosorbent assay for Antigen Detection
  1. "Molecular cloning, sequencing and expression of human interferon-gamma-inducible indoleamine 2,3-dioxygenase cDNA."Biochem. Biophys. Res. Commun. 168:1-8(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Primary structure of human indoleamine 2,3-dioxygenase deduced from the nucleotide sequence of its cDNA."Nucleic Acids Res. 18:367-367(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Gene structure of human indoleamine 2,3-dioxygenase."Biochem. Biophys. Res. Commun. 189:530-536(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan."Cancer Res. 67:7082-7087(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Evolution of vertebrate indoleamine 2,3-dioxygenases."J. Mol. Evol. 65:705-714(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase."Proc. Natl. Acad. Sci. U.S.A. 103:2611-2616(2006) [PubMed] [Europe PMC] [Abstract]