A Disintegrin And Metalloprotease 17 (ADAM17)

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CD156b; TACE; CSVP; Tumor Necrosis Factor,Alpha,Converting Enzyme; Disintegrin and metalloproteinase domain-containing protein 17; Snake venom-like protease

A Disintegrin And Metalloprotease 17 (ADAM17)

ADAM17 is a 70-kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases. ADAM17 is understood to be involved in the processing of tumor necrosis factor alpha (TNF-alpha;) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network. This process, which is also known as 'shedding', involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins (such as pro-TNF-alpha;), and is of known physiological importance.

ADAM17 was the first 'sheddase' to be identified, and is also understood to play a role in the release of a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands, and enzymes.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB555Hu01Recombinant A Disintegrin And Metalloprotease 17 (ADAM17)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB555Hu01Polyclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17)WB, ICC, IHC-P, IHC-F, ELISA
MAB555Hu22Monoclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
LAB555Hu71Biotin-Linked Polyclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17)IHC;WB;ELISA
LAB555Hu81FITC-Linked Polyclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17)IHC;ICC;IF;WB
Assay KitsSEB555HuELISA Kit for A Disintegrin And Metalloprotease 17 (ADAM17)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant A Disintegrin And Metalloprotease 17 (ADAM17)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17)Polyclonal Antibody Customized Service Offer
Assay KitsSEB555MuELISA Kit for A Disintegrin And Metalloprotease 17 (ADAM17)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB555Ra01Recombinant A Disintegrin And Metalloprotease 17 (ADAM17)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB555Ra01Polyclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17)WB, ICC, IHC-P, IHC-F, ELISA
MAB555Ra21Monoclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEB555RaELISA Kit for A Disintegrin And Metalloprotease 17 (ADAM17)Enzyme-linked immunosorbent assay for Antigen Detection
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  10. "Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation."Mol. Cell 37:551-566(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Inflammatory skin and bowel disease linked to ADAM17 deletion."N. Engl. J. Med. 365:1502-1508(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality."Nature 504:456-459(2013) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein."J. Virol. 88:1293-1307(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme."Proc. Natl. Acad. Sci. U.S.A. 95:3408-3412(1998) [PubMed] [Europe PMC] [Abstract]