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A Disintegrin And Metalloprotease 17 (ADAM17)

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CD156b; TACE; CSVP; Tumor Necrosis Factor,Alpha,Converting Enzyme; Disintegrin and metalloproteinase domain-containing protein 17; Snake venom-like protease

A Disintegrin And Metalloprotease 17 (ADAM17)
CCC B555
HGNC 195
MGI 1096335
PubMed 23441135
RGD 620404
UniProt P78536
Wiki ADAM17

ADAM17 is a 70-kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases. ADAM17 is understood to be involved in the processing of tumor necrosis factor alpha (TNF-alpha;) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network. This process, which is also known as 'shedding', involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins (such as pro-TNF-alpha;), and is of known physiological importance.

ADAM17 was the first 'sheddase' to be identified, and is also understood to play a role in the release of a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands, and enzymes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB555Hu01 Recombinant A Disintegrin And Metalloprotease 17 (ADAM17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB555Hu01 Polyclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) WB; IHC; ICC; IP.
MAB555Hu22 Monoclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) WB; IHC
LAB555Hu71 Biotin-Linked Polyclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) WB; IHC; ICC.
LAB555Hu81 FITC-Linked Polyclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) WB; IHC; ICC; IF.
MAB555Hu21 Monoclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) WB; IHC; ICC; IP.
MAB555Hu24 Monoclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) WB
MAB555Hu23 Monoclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) WB; IHC; ICC; IP.
Assay Kits SEB555Hu ELISA Kit for A Disintegrin And Metalloprotease 17 (ADAM17) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant A Disintegrin And Metalloprotease 17 (ADAM17) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) Polyclonal Antibody Customized Service Offer
Assay Kits SEB555Mu ELISA Kit for A Disintegrin And Metalloprotease 17 (ADAM17) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB555Ra01 Recombinant A Disintegrin And Metalloprotease 17 (ADAM17) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB555Ra01 Polyclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) WB; IHC; ICC; IP.
MAB555Ra21 Monoclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) WB; IHC; ICC; IP.
Assay Kits SEB555Ra ELISA Kit for A Disintegrin And Metalloprotease 17 (ADAM17) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha." Nature 385:733-736(1997) [PubMed] [Europe PMC] [Abstract]
  2. "A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells."Nature 385:729-733(1997) [PubMed] [Europe PMC] [Abstract]
  3. "TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha."J. Immunol. 160:4570-4579(1998) [PubMed] [Europe PMC] [Abstract]
  4. "Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding."Mol. Biol. Cell 13:2031-2044(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding."J. Biol. Chem. 278:3386-3394(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-alpha converting enzyme and of an alternatively translated polypeptide."J. Biol. Chem. 278:18617-18627(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Junctional adhesion molecule-C is a soluble mediator of angiogenesis."J. Immunol. 185:1777-1785(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation."Mol. Cell 37:551-566(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Inflammatory skin and bowel disease linked to ADAM17 deletion."N. Engl. J. Med. 365:1502-1508(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality."Nature 504:456-459(2013) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein."J. Virol. 88:1293-1307(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme."Proc. Natl. Acad. Sci. U.S.A. 95:3408-3412(1998) [PubMed] [Europe PMC] [Abstract]