Granulocyte Chemotactic Protein 2 (GCP2)

[Edit]

CXCL6; SCYB6; GCP2; CKA-3; Chemokine(C-X-C-Motif)ligand 6; Small Inducible Cytokine Subfamily B(Cys-X-Cys)Member 6; Chemokine alpha 3; Small-inducible cytokine B6

Granulocyte Chemotactic Protein 2 (GCP2)

Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2). As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes. It elicits its chemotactic effects by interacting with the chemokine receptors CXCR1 and CXCR2.The gene for CXCL6 is located on human chromosome 4 in a cluster with other CXC chemokine genes.

The GCP2 gene encodes a propeptide of 114 amino acids. Despite 85% identity of the first 270 nucleotides 5-prime of the transcription start sites, GCP2 and the other CXC chemokine gene ENA78 showed cell-specific differences in regulation.In vivo studies in rabbit demonstrated that GCP2 is a potent inflammatory mediator.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB570Hu01Recombinant Granulocyte Chemotactic Protein 2 (GCP2)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB570Hu01Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2)WB, ICC, IHC-P, IHC-F, ELISA
MAB570Hu22Monoclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2)WB, ICC, IHC-P, IHC-F, ELISA
LAB570Hu71Biotin-Linked Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2)IHC;WB;ELISA
LAB570Hu81FITC-Linked Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2)IHC;ICC;IF;WB
Assay KitsSEB570HuELISA Kit for Granulocyte Chemotactic Protein 2 (GCP2)Enzyme-linked immunosorbent assay for Antigen Detection
SCB570HuCLIA Kit for Granulocyte Chemotactic Protein 2 (GCP2)Chemiluminescent immunoassay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB570Mu01Recombinant Granulocyte Chemotactic Protein 2 (GCP2)SDS-PAGE; WB; ELISA; IP.
RPB570Mu02Recombinant Granulocyte Chemotactic Protein 2 (GCP2)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB570Mu01Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2)WB, ICC, IHC-P, IHC-F, ELISA
PAB570Mu02Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEB570MuELISA Kit for Granulocyte Chemotactic Protein 2 (GCP2)Enzyme-linked immunosorbent assay for Antigen Detection
SCB570MuCLIA Kit for Granulocyte Chemotactic Protein 2 (GCP2)Chemiluminescent immunoassay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB570Ra01Recombinant Granulocyte Chemotactic Protein 2 (GCP2)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB570Ra01Polyclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2)WB, ICC, IHC-P, IHC-F, ELISA
MAB570Ra21Monoclonal Antibody to Granulocyte Chemotactic Protein 2 (GCP2)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEB570RaELISA Kit for Granulocyte Chemotactic Protein 2 (GCP2)Enzyme-linked immunosorbent assay for Antigen Detection
SCB570RaCLIA Kit for Granulocyte Chemotactic Protein 2 (GCP2)Chemiluminescent immunoassay for Antigen Detection
  1. "Cloning and characterization of the human granulocyte chemotactic protein-2 gene."J. Immunol. 158:5257-5266(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning, bacterial expression and biological characterization of recombinant human granulocyte chemotactic protein-2 and differential expression of granulocyte chemotactic protein-2 and epithelial cell-derived neutrophil activating peptide-78 mRNAs."Eur. J. Biochem. 243:762-769(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines."Biochemistry 32:10170-10177(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8."J. Immunol. 150:1000-1010(1993) [PubMed] [Europe PMC] [Abstract]
  8. "The human CXC chemokine granulocyte chemotactic protein 2 (GCP-2)/CXCL6 possesses membrane-disrupting properties and is antibacterial."Antimicrob. Agents Chemother. 52:2599-2607(2008) [PubMed] [Europe PMC] [Abstract]