Major Basic Protein (MBP)

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PRG2; BMPG; Proteoglycan 2; Bone Marrow,Natural Killer Cell Activator; Eosinophil Granule Major Basic Protein; Proteoglycan 2,Bone Marrow; Pregnancy-associated major basic

Major Basic Protein (MBP)
  • Major basic protein The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases.PRG2 is a 117-residue protein that predominates in eosinophil granules. It is a potent enzyme against helminths and is toxic towards bacteria and mammalian cells in vitro.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB650Hu01 Recombinant Major Basic Protein (MBP) Positive Control; Immunogen; SDS-PAGE; WB.
CPB650Hu21 OVA Conjugated Major Basic Protein (MBP) Immunogen; SDS-PAGE; WB.
RPB650Hu02 Recombinant Major Basic Protein (MBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB650Hu01 Polyclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
MAB650Hu21 Monoclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
PAB650Hu08 Polyclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
MAB650Hu22 Monoclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
Assay Kits SEB650Hu ELISA Kit for Major Basic Protein (MBP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB650Mu01 Recombinant Major Basic Protein (MBP) Positive Control; Immunogen; SDS-PAGE; WB.
RPB650Mu02 Recombinant Major Basic Protein (MBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB650Mu01 Polyclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
PAB650Mu02 Polyclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
LAB650Mu71 Biotin-Linked Polyclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC.
Assay Kits SEB650Mu ELISA Kit for Major Basic Protein (MBP) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB650Mu CLIA Kit for Major Basic Protein (MBP) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB650Ra01 Recombinant Major Basic Protein (MBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB650Ra01 Polyclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
MAB650Ra21 Monoclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Major Basic Protein (MBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Major Basic Protein (MBP) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB650Po01 Recombinant Major Basic Protein (MBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB650Po01 Polyclonal Antibody to Major Basic Protein (MBP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Major Basic Protein (MBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Major Basic Protein (MBP) ELISA Kit Customized Service Offer
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  20. "Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissues."Biol. Reprod. 61:1083-1089(1999) [PubMed] [Europe PMC] [Abstract]
  21. "Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor."J. Biol. Chem. 275:31128-31133(2000) [PubMed] [Europe PMC] [Abstract]
  22. "Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment sites."J. Biol. Chem. 278:2106-2117(2003) [PubMed] [Europe PMC] [Abstract]
  23. "Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase." J. Biol. Chem. 283:28629-28640(2008) [PubMed] [Europe PMC] [Abstract]
  24. "Crystal structure of the eosinophil major basic protein at 1.8-A. An atypical lectin with a paradigm shift in specificity."J. Biol. Chem. 276:26197-26203(2001) [PubMed] [Europe PMC] [Abstract]
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