Major Basic Protein (MBP)

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PRG2; BMPG; Proteoglycan 2; Bone Marrow,Natural Killer Cell Activator; Eosinophil Granule Major Basic Protein; Proteoglycan 2,Bone Marrow; Pregnancy-associated major basic

Major Basic Protein (MBP)
  • Major basic protein The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases.PRG2 is a 117-residue protein that predominates in eosinophil granules. It is a potent enzyme against helminths and is toxic towards bacteria and mammalian cells in vitro.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB650Hu01Recombinant Major Basic Protein (MBP)SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling.
CPB650Hu21OVA Conjugated Major Basic Protein (MBP)Immunogen; Coating Antigen; Blocking Peptide; ELISA.
AntibodiesPAB650Hu01Polyclonal Antibody to Major Basic Protein (MBP)WB, ICC, IHC-P, IHC-F, ELISA
MAB650Hu21Monoclonal Antibody to Major Basic Protein (MBP)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
PAB650Hu08Polyclonal Antibody to Major Basic Protein (MBP)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEB650HuELISA Kit for Major Basic Protein (MBP)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB650Mu01Recombinant Major Basic Protein (MBP)SDS-PAGE; WB; ELISA; IP.
RPB650Mu02Recombinant Major Basic Protein (MBP)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB650Mu01Polyclonal Antibody to Major Basic Protein (MBP)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
PAB650Mu02Polyclonal Antibody to Major Basic Protein (MBP)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
LAB650Mu71Biotin-Linked Polyclonal Antibody to Major Basic Protein (MBP)IHC;WB;ELISA
Assay KitsSEB650MuELISA Kit for Major Basic Protein (MBP)Enzyme-linked immunosorbent assay for Antigen Detection
SCB650MuCLIA Kit for Major Basic Protein (MBP)Chemiluminescent immunoassay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB650Ra01Recombinant Major Basic Protein (MBP)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB650Ra01Polyclonal Antibody to Major Basic Protein (MBP)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
MAB650Ra21Monoclonal Antibody to Major Basic Protein (MBP)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
Assay Kitsn/aCLIA Kit for Major Basic Protein (MBP)CLIA Kit Customized Service Offer
n/aELISA Kit for Major Basic Protein (MBP)ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB650Po01Recombinant Major Basic Protein (MBP)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB650Po01Polyclonal Antibody to Major Basic Protein (MBP)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Major Basic Protein (MBP)CLIA Kit Customized Service Offer
n/aELISA Kit for Major Basic Protein (MBP)ELISA Kit Customized Service Offer
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  21. "Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor."J. Biol. Chem. 275:31128-31133(2000) [PubMed] [Europe PMC] [Abstract]
  22. "Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment sites."J. Biol. Chem. 278:2106-2117(2003) [PubMed] [Europe PMC] [Abstract]
  23. "Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase." J. Biol. Chem. 283:28629-28640(2008) [PubMed] [Europe PMC] [Abstract]
  24. "Crystal structure of the eosinophil major basic protein at 1.8-A. An atypical lectin with a paradigm shift in specificity."J. Biol. Chem. 276:26197-26203(2001) [PubMed] [Europe PMC] [Abstract]
  25. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]