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Basal Cell Adhesion Molecule (BCAM)

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CD239; BCAM; AU; LU; MSK19; Lutheran Blood Group Glycoprotein; Auberger B antigen; B-CAM cell surface glycoprotein; F8/G253 antigen

Basal Cell Adhesion Molecule (BCAM)
CCC B716
HGNC 6722
MGI 1929940
PubMed 10728810
RGD 68378
UniProt P50895
Wiki BCAM

Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail.

This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two transcript variants encoding different isoforms have been found for this gene.The BCAM gene encodes a glycoprotein expressed on cell surfaces. It is a member of the immunoglobulin superfamily of receptors and cell adhesion molecules. When expressed on erythrocytes, BCAM constitutes the Lutheran (Lu) and Auberger (Au) blood group antigens.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB716Hu01 Recombinant Basal Cell Adhesion Molecule (BCAM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB716Hu01 Polyclonal Antibody to Basal Cell Adhesion Molecule (BCAM) WB; IHC; ICC; IP.
MAB716Hu21 Monoclonal Antibody to Basal Cell Adhesion Molecule (BCAM) WB; IHC; ICC; IP.
Assay Kits SEB716Hu ELISA Kit for Basal Cell Adhesion Molecule (BCAM) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Basal Cell Adhesion Molecule (BCAM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Basal Cell Adhesion Molecule (BCAM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Basal Cell Adhesion Molecule (BCAM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Basal Cell Adhesion Molecule (BCAM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Basal Cell Adhesion Molecule (BCAM) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Basal Cell Adhesion Molecule (BCAM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Basal Cell Adhesion Molecule (BCAM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Basal Cell Adhesion Molecule (BCAM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Basal Cell Adhesion Molecule (BCAM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Basal Cell Adhesion Molecule (BCAM) ELISA Kit Customized Service Offer
  1. "The Lutheran blood group glycoprotein, another member of the immunoglobulin superfamily, is widely expressed in human tissues and is developmentally regulated in human liver."Proc. Natl. Acad. Sci. U.S.A. 92:5496-5500(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily."Cancer Res. 54:5761-5765(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Use of domain-deletion mutants to locate Lutheran blood group antigens to each of the five immunoglobulin superfamily domains of the Lutheran glycoprotein: elucidation of the molecular basis of the Lu(a)/Lu(b) and the Au(a)/Au(b) polymorphisms."Blood 89:4219-4225(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Organization of the human LU gene and molecular basis of the Lu(a)/Lu(b) blood group polymorphism."Blood 89:4608-4616(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Basal cell adhesion molecule/lutheran protein. The receptor critical for sickle cell adhesion to laminin."J. Clin. Invest. 101:2550-2558(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Protein kinase A-dependent phosphorylation of Lutheran/basal cell adhesion molecule glycoprotein regulates cell adhesion to laminin alpha5."J. Biol. Chem. 280:30055-30062(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  11. "Different inactivating mutations in the LU genes of three individuals with the Lutheran-null phenotype."Transfusion 47:492-498(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "The Laminin 511/521-binding site on the Lutheran blood group glycoprotein is located at the flexible junction of Ig domains 2 and 3."Blood 110:3398-3406(2007) [PubMed] [Europe PMC] [Abstract]