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B-Cell CLL/Lymphoma 3 (Bcl3)

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BCL3; BCL4; B-Cell Lymphoma 3-Encoded Protein; B-Cell Lymphoma 3-Encoded Protein; Chronic Lymphatic Leukemia Protein; Proto-oncogene BCL3

B-Cell CLL/Lymphoma 3 (Bcl3)
CCC B734
HGNC 998
MGI 88140
PubMed 8196632
RGD 1589465
UniProt P20749
Wiki BCL3

B-cell lymphoma 3-encoded protein is  a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins.

This protein functions as a transcriptional coactivator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.Wulczyn et al. (1992) and Franzoso et al. (1992) found that the BCL3 gene encodes an inhibitor (antagonist) for subunit 2 of nuclear factor kappa-B (NFKB2).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant B-Cell CLL/Lymphoma 3 (Bcl3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to B-Cell CLL/Lymphoma 3 (Bcl3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to B-Cell CLL/Lymphoma 3 (Bcl3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for B-Cell CLL/Lymphoma 3 (Bcl3) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell CLL/Lymphoma 3 (Bcl3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB734Mu01 Recombinant B-Cell CLL/Lymphoma 3 (Bcl3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB734Mu01 Polyclonal Antibody to B-Cell CLL/Lymphoma 3 (Bcl3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for B-Cell CLL/Lymphoma 3 (Bcl3) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell CLL/Lymphoma 3 (Bcl3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB734Ra01 Recombinant B-Cell CLL/Lymphoma 3 (Bcl3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB734Ra01 Polyclonal Antibody to B-Cell CLL/Lymphoma 3 (Bcl3) WB; IHC; ICC; IP.
Assay Kits SEB734Ra ELISA Kit for B-Cell CLL/Lymphoma 3 (Bcl3) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control."Cell 60:991-997(1990) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic structure of the candidate proto-oncogene BCL3."Genomics 24:120-126(1994) [PubMed] [Europe PMC] [Abstract]
  4. "The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers."Cell 72:729-739(1993) [PubMed] [Europe PMC] [Abstract]
  5. "NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes."EMBO J. 18:4766-4778(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators."Oncogene 18:3316-3323(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination."J. Biol. Chem. 278:26102-26110(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family."EMBO J. 20:6180-6190(2001) [PubMed] [Europe PMC] [Abstract]
  9. "GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity."Mol. Cell 16:35-45(2004) [PubMed] [Europe PMC] [Abstract]