Ribonuclease A3 (RNASE3)

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Rnase-A3; RnaseA3; ECP; RNS3; Ribonuclease,RNase A Family 3; Eosinophil Cationic Protein

Ribonuclease A3 (RNASE3)

Eosinophil cationic protein, like eosinophil-derived neurotoxin, is localized to the granule matrix of the eosinophil. Both proteins possess neurotoxic, helminthotoxic, and ribonucleolytic activities. The cDNA sequences of the genes encoding these 2 proteins and the deduced amino acid sequences indicate that the genes belong to the ribonuclease gene superfamily. Hamann et al. (1990) demonstrated remarkable similarities of eosinophil-derived neurotoxin and eosinophil cationic protein, symbolized RNS2 and RNS3, respectively, in noncoding sequences, introns, and flanking regions, as well as the previously known coding regions. A single intron in the 5-prime untranslated region and an intronless coding region appear to be features common to many members of the RNase gene superfamily.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB758Hu01 Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
RPB758Hu02 Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
RPB758Hu03 Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB758Hu01 Polyclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
MAB758Hu22 Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
MAB758Hu21 Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB
LAB758Hu72 Biotin-Linked Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC.
PAB758Hu02 Polyclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
MAB758Hu23 Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
MAB758Hu24 Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
MAB758Hu25 Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
LAB758Hu74 Biotin-Linked Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC.
LAB758Hu76 Biotin-Linked Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC.
Assay Kits SEB758Hu ELISA Kit for Ribonuclease A3 (RNASE3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB758Mu01 Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
RPB758Mu02 Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
RPB758Mu03 Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB758Mu01 Polyclonal Antibody to Ribonuclease A3 (RNASE3) WB
MAB758Mu21 Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
LAB758Mu72 Biotin-Linked Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC.
MAB758Mu22 Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
Assay Kits SEB758Mu ELISA Kit for Ribonuclease A3 (RNASE3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB758Ra01 Recombinant Ribonuclease A3 (RNASE3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB758Ra01 Polyclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
MAB758Ra21 Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC; IP.
LAB758Ra72 Biotin-Linked Monoclonal Antibody to Ribonuclease A3 (RNASE3) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Ribonuclease A3 (RNASE3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribonuclease A3 (RNASE3) ELISA Kit Customized Service Offer
  1. "Human eosinophil cationic protein. Molecular cloning of a cytotoxin and helminthotoxin with ribonuclease activity."J. Exp. Med. 170:163-176(1989) [PubMed] [Europe PMC] [Abstract]
  2. "Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily."Genomics 7:535-546(1990) [PubMed] [Europe PMC] [Abstract]
  3. "Eosinophil cationic protein cDNA. Comparison with other toxic cationic proteins and ribonucleases."J. Immunol. 143:952-955(1989) [PubMed] [Europe PMC] [Abstract]
  4. "Sequence variation at two eosinophil-associated ribonuclease loci in humans."Genetics 156:1949-1958(2000) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease."Proc. Natl. Acad. Sci. U.S.A. 83:3146-3150(1986) [PubMed] [Europe PMC] [Abstract]
  8. "Antibiotic proteins of human polymorphonuclear leukocytes."Proc. Natl. Acad. Sci. U.S.A. 86:5610-5614(1989) [PubMed] [Europe PMC] [Abstract]
  9. "Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase." J. Biol. Chem. 283:28629-28640(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Bactericidal and membrane disruption activities of the eosinophil cationic protein are largely retained in an N-terminal fragment."Biochem. J. 421:425-434(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Eosinophil cationic protein aggregation: identification of an N-terminus amyloid prone region."Biomacromolecules 11:1983-1990(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure of eosinophil cationic protein at 2.4 A resolution."Biochemistry 38:16794-16801(1999) [PubMed] [Europe PMC] [Abstract]
  13. "Three-dimensional crystal structure of human eosinophil cationic protein (RNase 3) at 1.75 A resolution."J. Mol. Biol. 300:1297-1307(2000) [PubMed] [Europe PMC] [Abstract]
  14. "The crystal structure of eosinophil cationic protein in complex with 2',5'-ADP at 2.0 A resolution reveals the details of the ribonucleolytic active site."Biochemistry 41:12100-12106(2002) [PubMed] [Europe PMC] [Abstract]