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Major Vault Protein (MVP)

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LRP; VAULT1; Lung resistance-related protein

Major Vault Protein (MVP)
CCC B764
HGNC 7531
MGI 1925638
PubMed 18759128
RGD 70932
UniProt Q14764
Wiki MVP

Major vault protein is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells.

The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.L-MVP, that contains a 41-bp stretch in the 5-prime region that is intronic in the shorter S-MVP splice variant. This 41-bp stretch introduces an upstream ORF encoding a deduced 18-amino acid peptide.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB764Hu01 Recombinant Major Vault Protein (MVP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAB764Hu21 Monoclonal Antibody to Major Vault Protein (MVP) WB; IHC; ICC; IP.
PAB764Hu01 Polyclonal Antibody to Major Vault Protein (MVP) WB; IHC; ICC; IP.
Assay Kits SEB764Hu ELISA Kit for Major Vault Protein (MVP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Major Vault Protein (MVP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Major Vault Protein (MVP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Major Vault Protein (MVP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Major Vault Protein (MVP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Major Vault Protein (MVP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Major Vault Protein (MVP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Major Vault Protein (MVP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Major Vault Protein (MVP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Major Vault Protein (MVP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Major Vault Protein (MVP) ELISA Kit Customized Service Offer
  1. "The drug resistance-related protein LRP is the human major vault protein."Nat. Med. 1:578-582(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and initial analysis of the human multidrug resistance-related MVP/LRP gene promoter."Biochem. Biophys. Res. Commun. 278:125-133(2000) [PubMed] [Europe PMC] [Abstract]
  4. "A small upstream open reading frame causes inhibition of human major vault protein expression from a ubiquitous mRNA splice variant."FEBS Lett. 494:99-104(2001) [PubMed] [Europe PMC] [Abstract]
  5. , Submitted (JAN-2005) to UniProtKB
  6. "Vaults and telomerase share a common subunit, TEP1."J. Biol. Chem. 274:32712-32717(1999) [PubMed] [Europe PMC] [Abstract]
  7. "PTEN associates with the vault particles in HeLa cells."J. Biol. Chem. 277:40247-40252(2002) [PubMed] [Europe PMC] [Abstract]
  8. "The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling."J. Biol. Chem. 279:29374-29385(2004) [PubMed] [Europe PMC] [Abstract]
  9. "A novel human zinc finger protein ZNF540 interacts with MVP and inhibits transcriptional activities of the ERK signal pathway."Biochem. Biophys. Res. Commun. 347:288-296(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling."FEBS J. 273:793-804(2006) [PubMed] [Europe PMC] [Abstract]
  11. "The major vault protein is responsive to and interferes with interferon-gamma-mediated STAT1 signals."J. Cell Sci. 119:459-469(2006) [PubMed] [Europe PMC] [Abstract]
  12. "Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1."Mol. Cell. Biol. 28:7066-7080(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  16. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Solution structure of a two-repeat fragment of major vault protein."J. Mol. Biol. 356:444-452(2006) [PubMed] [Europe PMC] [Abstract]