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A Disintegrin And Metalloprotease 9 (ADAM9)

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MCMP; MDC9; Mltng; Meltrin Gamma; Metalloprotease/disintegrin/cysteine-rich protein 9; Myeloma cell metalloproteinase; Cellular disintegrin-related protein

A Disintegrin And Metalloprotease 9 (ADAM9)
CCC B829
HGNC 216
MGI 105376
PubMed 14997207
RGD 621473
UniProt Q13443
Wiki ADAM9
Disintegrin and metalloproteinase domain-containing protein 9 is a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis.
The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Two alternative splice variants have been identified, encoding distinct isoforms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB829Hu01 Recombinant A Disintegrin And Metalloprotease 9 (ADAM9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB829Hu01 Polyclonal Antibody to A Disintegrin And Metalloprotease 9 (ADAM9) WB; IHC; ICC; IP.
MAB829Hu22 Monoclonal Antibody to A Disintegrin And Metalloprotease 9 (ADAM9) WB; IHC; ICC; IP.
LAB829Hu81 FITC-Linked Polyclonal Antibody to A Disintegrin And Metalloprotease 9 (ADAM9) WB; IHC; ICC; IF.
LAB829Hu71 Biotin-Linked Polyclonal Antibody to A Disintegrin And Metalloprotease 9 (ADAM9) WB; IHC; ICC.
Assay Kits SEB829Hu ELISA Kit for A Disintegrin And Metalloprotease 9 (ADAM9) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant A Disintegrin And Metalloprotease 9 (ADAM9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to A Disintegrin And Metalloprotease 9 (ADAM9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to A Disintegrin And Metalloprotease 9 (ADAM9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for A Disintegrin And Metalloprotease 9 (ADAM9) CLIA Kit Customized Service Offer
n/a ELISA Kit for A Disintegrin And Metalloprotease 9 (ADAM9) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB829Ra01 Recombinant A Disintegrin And Metalloprotease 9 (ADAM9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB829Ra01 Polyclonal Antibody to A Disintegrin And Metalloprotease 9 (ADAM9) WB; IHC; ICC; IP.
MAB829Ra21 Monoclonal Antibody to A Disintegrin And Metalloprotease 9 (ADAM9) WB; IHC; ICC; IP.
Assay Kits SEB829Ra ELISA Kit for A Disintegrin And Metalloprotease 9 (ADAM9) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB829Ra CLIA Kit for A Disintegrin And Metalloprotease 9 (ADAM9) Chemiluminescent immunoassay for Antigen Detection.
  1. "MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains."J. Cell Biol. 132:717-726(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning of a novel membrane-linked metalloproteinase from human myeloma cells."Biochem. J. 318:459-462(1996) [PubMed] [Europe PMC] [Abstract]
  3. "A secreted form of human ADAM9 has an alpha-secretase activity for APP."Biochem. Biophys. Res. Commun. 293:800-805(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes."Biochem. Biophys. Res. Commun. 230:335-339(1997) [PubMed] [Europe PMC] [Abstract]
  7. "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1."J. Biol. Chem. 274:31693-31699(1999) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice." Am. J. Hum. Genet. 84:683-691(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Exploring the substrate affinities of MMP-3, ADAM-9 and ADAM-10 using molecular modelling and dynamics simulations."Submitted (JUN-2002) to the PDB data bank