Interleukin 7 Receptor (IL7R)

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CDW127; CD127; IL-7R-Alpha

Interleukin 7 Receptor (IL7R)
Interleukin-7 receptor is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB905Hu01Recombinant Interleukin 7 Receptor (IL7R)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB905Hu01Polyclonal Antibody to Interleukin 7 Receptor (IL7R)WB, ICC, IHC-P, IHC-F, ELISA
MAB905Hu22Monoclonal Antibody to Interleukin 7 Receptor (IL7R)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEB905HuELISA Kit for Interleukin 7 Receptor (IL7R)Enzyme-linked immunosorbent assay

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB905Mu01Recombinant Interleukin 7 Receptor (IL7R)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB905Mu01Polyclonal Antibody to Interleukin 7 Receptor (IL7R)WB, ICC, IHC-P, IHC-F, ELISA
LAB905Mu71Biotin-Linked Polyclonal Antibody to Interleukin 7 Receptor (IL7R)IHC;WB;ELISA
Assay Kitsn/aCLIA Kit for Interleukin 7 Receptor (IL7R)CLIA Kit Customized Service Offer
n/aELISA Kit for Interleukin 7 Receptor (IL7R)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB905Ra01Recombinant Interleukin 7 Receptor (IL7R)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB905Ra01Polyclonal Antibody to Interleukin 7 Receptor (IL7R)WB, ICC, IHC-P, IHC-F, ELISA
MAB905Ra21Monoclonal Antibody to Interleukin 7 Receptor (IL7R)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEB905RaELISA Kit for Interleukin 7 Receptor (IL7R)Enzyme-linked immunosorbent assay
  1. "Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily."Cell 60:941-951(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter."Mol. Cell. Biol. 11:3052-3059(1991) [PubMed] [Europe PMC] [Abstract]
  3. "Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency."Nat. Genet. 20:394-397(1998) [PubMed] [Europe PMC] [Abstract]
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  8. "A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency."Blood 96:2803-2807(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis."Nat. Genet. 39:1083-1091(2007) [PubMed] [Europe PMC] [Abstract]