Aggrecan (AGC)
[Edit]ACAN; AGC1; AGCAN; CSPG1; CSPCP; CSPGCP; MSK16; SEDK; Cartilage-specific proteoglycan core protein; Large Aggregating Proteoglycan; Chondroitin Sulfate Proteoglycan 1
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Aggrecan, or large aggregating proteoglycan, is a proteoglycan, or a protein modified with carbohydrates; the human form of the protein is 2316 amino acids long and can be expressed in multiple isoforms due to alternative splicing. Along with Type-II collagen, aggrecan forms a major structural component of cartilage, particularly articular cartilage.
Aggrecan consists of two globular structural domains at the N-terminal end and one globular domain at the C-terminal end, separated by a large domain heavily modified with glycosaminoglycans. The two main modifier moieties are themselves arranged into distinct regions, a chondroitin sulfate and a keratan sulfate region.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB908Hu01 | Recombinant Aggrecan (AGC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB908Hu02 | Recombinant Aggrecan (AGC) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| RPB908Hu03 | Recombinant Aggrecan (AGC) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB908Hu01 | Polyclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IP. |
| MAB908Hu22 | Monoclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IP. | |
| PAB908Hu02 | Polyclonal Antibody to Aggrecan (AGC) | WB | |
| PAB908Hu03 | Polyclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IP. | |
| LAB908Hu71 | Biotin-Linked Polyclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC. | |
| LAB908Hu81 | FITC-Linked Polyclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IF. | |
| MAB908Hu21 | Monoclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB908Hu | ELISA Kit for Aggrecan (AGC) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SCB908Hu | CLIA Kit for Aggrecan (AGC) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB908Mu01 | Recombinant Aggrecan (AGC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB908Mu02 | Recombinant Aggrecan (AGC) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB908Mu01 | Polyclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IP. |
| PAB908Mu02 | Polyclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IP. | |
| LAB908Mu71 | Biotin-Linked Polyclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC. | |
| Assay Kits | SEB908Mu | ELISA Kit for Aggrecan (AGC) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB908Ra01 | Recombinant Aggrecan (AGC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB908Ra02 | Recombinant Aggrecan (AGC) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB908Ra01 | Polyclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IP. |
| PAB908Ra02 | Polyclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IP. | |
| LAB908Ra71 | Biotin-Linked Polyclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC. | |
| Assay Kits | SEB908Ra | ELISA Kit for Aggrecan (AGC) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Oryctolagus cuniculus (Rabbit)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB908Rb01 | Recombinant Aggrecan (AGC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB908Rb51 | Polyclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IP. |
| MAB908Rb21 | Monoclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB908Rb | ELISA Kit for Aggrecan (AGC) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Aggrecan (AGC) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Aggrecan (AGC) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Aggrecan (AGC) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SEB908Po | ELISA Kit for Aggrecan (AGC) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB908Bo01 | Recombinant Aggrecan (AGC) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB908Bo01 | Polyclonal Antibody to Aggrecan (AGC) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Aggrecan (AGC) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Aggrecan (AGC) | ELISA Kit Customized Service Offer |
- "Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms."J. Biol. Chem. 266:894-902(1991) [PubMed] [Europe PMC] [Abstract]
- "Catabolism of aggrecan by explant cultures of human articular cartilage in the presence of retinoic acid."Arch. Biochem. Biophys. 322:22-30(1995) [PubMed] [Europe PMC] [Abstract]
- "The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain."J. Clin. Invest. 89:1512-1516(1992) [PubMed] [Europe PMC] [Abstract]
- "Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes."Biochim. Biophys. Acta 1219:613-622(1994) [PubMed] [Europe PMC] [Abstract]
- "The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis."Arthritis Rheum. 36:1214-1222(1993) [PubMed] [Europe PMC] [Abstract]
- "Length variation in the keratan sulfate domain of mammalian aggrecan."Matrix Biol. 14:323-328(1994) [PubMed] [Europe PMC] [Abstract]
- "Age-related changes in the content of the C-terminal region of aggrecan in human articular cartilage."Biochem. J. 313:933-940(1996) [PubMed] [Europe PMC] [Abstract]
- "A new epidermal growth factor-like domain in the human core protein for the large cartilage-specific proteoglycan. Evidence for alternative splicing of the domain."J. Biol. Chem. 264:15747-15750(1989) [PubMed] [Europe PMC] [Abstract]
- "A mutation in the variable repeat region of the aggrecan gene (AGC1) causes a form of spondyloepiphyseal dysplasia associated with severe, premature osteoarthritis."Am. J. Hum. Genet. 77:484-490(2005) [PubMed] [Europe PMC] [Abstract]
- "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
- "Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan."J. Biol. Chem. 282:24591-24598(2007) [PubMed] [Europe PMC] [Abstract]
- "A recessive skeletal dysplasia, SEMD aggrecan type, results from a missense mutation affecting the C-type lectin domain of aggrecan."Am. J. Hum. Genet. 84:72-79(2009) [PubMed] [Europe PMC] [Abstract]
- "A missense mutation in the aggrecan C-type lectin domain disrupts extracellular matrix interactions and causes dominant familial osteochondritis dissecans."Am. J. Hum. Genet. 86:126-137(2010) [PubMed] [Europe PMC] [Abstract]