Choline Acetyltransferase (ChAT)

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CMS1A; CMS1A2; CHOACTase; Choline acetylase

Choline Acetyltransferase (ChAT)
Choline acetyltransferase (EC 2.3.1.6; abbreviated "ChAT") is an enzyme that is synthesized within the body of a neuron. It is then transferred to the nerve terminal via axoplasmic flow. The role of choline acetyltransferase is to join Acetyl-CoA to choline, resulting in the formation of the neurotransmitter acetylcholine. Cholinergic systems are implicated in numerous neurologic functions. Alteration in some cholinergic neurons may account for the disturbances of Alzheimer disease. The protein encoded by this gene synthesizes the neurotransmitter acetylcholine. Alternative splice variants have been found that contain alternative 5' untranslated exons. Three of the four described splice variants encode identical 69 kDa proteins while one variant encodes both the 69 kDa and a larger 82 kDa protein.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB929Hu01Recombinant Choline Acetyltransferase (ChAT)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB929Hu01Polyclonal Antibody to Choline Acetyltransferase (ChAT)WB, ICC, IHC-P, IHC-F, ELISA
MAB929Hu21Monoclonal Antibody to Choline Acetyltransferase (ChAT)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEB929HuELISA Kit for Choline Acetyltransferase (ChAT)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB929Mu01Recombinant Choline Acetyltransferase (ChAT)SDS-PAGE; WB; ELISA; IP.
RPB929Mu02Recombinant Choline Acetyltransferase (ChAT)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB929Mu01Polyclonal Antibody to Choline Acetyltransferase (ChAT)WB, ICC, IHC-P, IHC-F, ELISA
PAB929Mu02Polyclonal Antibody to Choline Acetyltransferase (ChAT)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEB929MuELISA Kit for Choline Acetyltransferase (ChAT)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB929Ra01Recombinant Choline Acetyltransferase (ChAT)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB929Ra01Polyclonal Antibody to Choline Acetyltransferase (ChAT)WB, ICC, IHC-P, IHC-F, ELISA
MAB929Ra21Monoclonal Antibody to Choline Acetyltransferase (ChAT)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEB929RaELISA Kit for Choline Acetyltransferase (ChAT)Enzyme-linked immunosorbent assay for Antigen Detection
SCB929RaCLIA Kit for Choline Acetyltransferase (ChAT)Chemiluminescent immunoassay for Antigen Detection
  1. "A complementary DNA for human choline acetyltransferase induces two forms of enzyme with different molecular weights in cultured cells."Brain Res. Mol. Brain Res. 16:287-294(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Choline acetyltransferase mutations cause myasthenic syndrome associated with episodic apnea in humans."Proc. Natl. Acad. Sci. U.S.A. 98:2017-2022(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Two mRNAs are transcribed from the human gene for choline acetyltransferase."DNA Cell Biol. 11:593-603(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Human choline acetyltransferase (CHAT): partial gene sequence and potential control regions."Genomics 12:412-416(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Conservation of amino acid sequences between human and porcine choline acetyltransferase."J. Neurochem. 51:1843-1845(1988) [PubMed] [Europe PMC] [Abstract]
  8. "Isolation and sub-chromosomal localization of a DNA fragment of the human choline acetyltransferase gene."Neurosci. Lett. 132:191-194(1991) [PubMed] [Europe PMC] [Abstract]
  9. "Substrate binding and catalytic mechanism of human choline acetyltransferase."Biochemistry 45:14621-14631(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Congenital myasthenic syndrome with episodic apnea in patients homozygous for a CHAT missense mutation."Arch. Neurol. 60:761-763(2003) [PubMed] [Europe PMC] [Abstract]