Hepcidin (Hepc)
[Edit]HAMP; HFE2B; PLTR; LEAP1; Hepcidin Antimicrobial Peptide; Liver-expressed antimicrobial peptide 1; Putative liver tumor regressor
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Hepcidin is a peptide hormone produced by the liver discovered in 2000, that appears to be the master regulator of iron homeostasis in humans and other mammals. In humans, HAMP is the gene that encodes for hepcidin.
Hepcidin preprohormone, prohormone and hormone size are 84, 60 and 25 amino acids respectively. 20 and 22 amino acid forms of Hepcidin also exist in the urine. The N terminal region is required for function, and deletion of 5 N-terminal peptides results in a loss of function. Hepcidin has a beta-sheet rich structure with 4 disulfide bonds. Hepcidin directly inhibits ferroportin, a protein that transports iron out of cells that store it. This prevents enterocytes of the intestines from secreting iron into the hepatic portal system, reducing iron absorption.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB979Hu01 | Recombinant Hepcidin (Hepc) | Positive Control; Immunogen; SDS-PAGE; WB. |
| EPB979Hu61 | Eukaryotic Hepcidin (Hepc) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| CPB979Hu12 | BSA Conjugated Hepcidin (Hepc) | Immunogen; SDS-PAGE; WB. | |
| CPB979Hu22 | OVA Conjugated Hepcidin (Hepc) | Immunogen; SDS-PAGE; WB. | |
| CPB979Hu23 | OVA Conjugated Hepcidin (Hepc) | Immunogen; SDS-PAGE; WB. | |
| CPB979Hu21 | OVA Conjugated Hepcidin (Hepc) | Immunogen; SDS-PAGE; WB. | |
| APB979Hu61 | Active Hepcidin (Hepc) | Cell culture; Activity Assays. | |
| Antibodies | PAB979Hu01 | Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. |
| LAB979Hu71 | Biotin-Linked Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC. | |
| LAB979Hu81 | FITC-Linked Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IF. | |
| PAB979Hu06 | Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. | |
| MAB979Hu26 | Monoclonal Antibody to Hepcidin (Hepc) | WB | |
| PAB979Hu07 | Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. | |
| PAB979Hu09 | Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. | |
| MAB979Hu22 | Monoclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. | |
| MAB979Hu21 | Monoclonal Antibody to Hepcidin (Hepc) | IHC. | |
| PAB979Mi01 | Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. | |
| PAB979Hu08 | Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. | |
| Assay Kits | SCB979Hu | CLIA Kit for Hepcidin (Hepc) | Chemiluminescent immunoassay for Antigen Detection. |
| CEB979Hu | ELISA Kit for Hepcidin (Hepc) | Enzyme-linked immunosorbent assay for Antigen Detection. | |
| SEB979Hu | ELISA Kit for Hepcidin (Hepc) | Enzyme-linked immunosorbent assay for Antigen Detection. | |
| CCB979Hu | CLIA Kit for Hepcidin (Hepc) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB979Mu01 | Recombinant Hepcidin (Hepc) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPB979Mu02 | Recombinant Hepcidin (Hepc) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB979Mu01 | Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. |
| LAB979Mu71 | Biotin-Linked Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC. | |
| LAB979Mu81 | FITC-Linked Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IF. | |
| PAB979Mu02 | Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. | |
| Assay Kits | CEB979Mu | ELISA Kit for Hepcidin (Hepc) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SEB979Mu | ELISA Kit for Hepcidin (Hepc) | Enzyme-linked immunosorbent assay for Antigen Detection. | |
| HEB979Mu | High Sensitive ELISA Kit for Hepcidin (Hepc) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB979Ra01 | Recombinant Hepcidin (Hepc) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB979Ra01 | Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. |
| MAB979Ra21 | Monoclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. | |
| Assay Kits | CEB979Ra | ELISA Kit for Hepcidin (Hepc) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| SEB979Ra | ELISA Kit for Hepcidin (Hepc) | Enzyme-linked immunosorbent assay for Antigen Detection. | |
| HEB979Ra | High Sensitive ELISA Kit for Hepcidin (Hepc) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Canis familiaris; Canine (Dog)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB979Ca01 | Recombinant Hepcidin (Hepc) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | n/a | Monoclonal Antibody to Hepcidin (Hepc) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Hepcidin (Hepc) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | SEB979Ca | ELISA Kit for Hepcidin (Hepc) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB979Po01 | Recombinant Hepcidin (Hepc) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB979Po01 | Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. |
| MAB979Po21 | Monoclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. | |
| Assay Kits | CEB979Po | ELISA Kit for Hepcidin (Hepc) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB979Bo01 | Recombinant Hepcidin (Hepc) | Positive Control; Immunogen; SDS-PAGE; WB. |
| CPB979Bo11 | BSA Conjugated Hepcidin (Hepc) | Immunogen; SDS-PAGE; WB. | |
| CPB979Bo21 | OVA Conjugated Hepcidin (Hepc) | Immunogen; SDS-PAGE; WB. | |
| CPB979Bo22 | OVA Conjugated Hepcidin (Hepc) | Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAB979Bo01 | Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. |
| MAB979Bo21 | Monoclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. | |
| PAB979Bo08 | Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. | |
| PAB979Bo09 | Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. | |
| PAB979Mi01 | Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. | |
| Assay Kits | SEB979Bo | ELISA Kit for Hepcidin (Hepc) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Pan-species (General)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPB979Ge01 | Recombinant Hepcidin (Hepc) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAB979Ge01 | Polyclonal Antibody to Hepcidin (Hepc) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Hepcidin (Hepc) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Hepcidin (Hepc) | ELISA Kit Customized Service Offer |
- "Hepcidin: a urinary antimicrobial peptide synthesized in the liver."J. Biol. Chem. 276:7806-7810(2001) [PubMed] [Europe PMC] [Abstract]
- "LEAP-1, a novel highly disulfide-bonded human peptide exhibits antimicrobial activity."FEBS Lett. 480:147-150(2000) [PubMed] [Europe PMC] [Abstract]
- "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Chemical synthesis of beta-defensins and LEAP-1/hepcidin."J. Pept. Res. 59:241-248(2002) [PubMed] [Europe PMC] [Abstract]
- "Hepcidin and iron homeostasis."Biochim. Biophys. Acta 1823:1434-1443(2012) [PubMed] [Europe PMC] [Abstract]
- "The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis."J. Biol. Chem. 277:37597-37603(2002) [PubMed] [Europe PMC] [Abstract]
- "Hepcidin revisited, disulfide connectivity, dynamics, and structure."J. Biol. Chem. 284:24155-24167(2009) [PubMed] [Europe PMC] [Abstract]
- "Identification of new mutations of the HFE, hepcidin, and transferrin receptor 2 genes by denaturing HPLC analysis of individuals with biochemical indications of iron overload."Clin. Chem. 49:1981-1988(2003) [PubMed] [Europe PMC] [Abstract]
- "Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis."Hum. Mol. Genet. 12:2241-2247(2003) [PubMed] [Europe PMC] [Abstract]
- "Screening hepcidin for mutations in juvenile hemochromatosis: identification of a new mutation (C70R)."Blood 103:2407-2409(2004) [PubMed] [Europe PMC] [Abstract]
- "HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype."Blood 103:2835-2840(2004) [PubMed] [Europe PMC] [Abstract]
- "A homozygous HAMP mutation in a multiply consanguineous family with pseudo-dominant juvenile hemochromatosis."Clin. Genet. 65:378-383(2004) [PubMed] [Europe PMC] [Abstract]