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Interleukin 33 (IL33)

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DV27; C9ORF26; IL1F11; NFHEV; Interleukin-1 Family, Member 11; Nuclear factor from high endothelial venules

Interleukin 33 (IL33)
CCC B980
HGNC 16028
MGI 1924375
PubMed 23439054
RGD 1311155
UniProt O95760
Wiki Interleukin_33

Interleukin 33 (IL-33) is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. This cytokine was previously named NF-HEV 'nuclear factor (NF) in high endothelial venules' (HEVs) since it was originally identified in these specialized cells. IL-33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. The induction of type 2 cytokines by IL-33 in vivo is believed to induce the severe pathological changes observed in mucosal organs following administration of IL-33.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB980Hu01 Recombinant Interleukin 33 (IL33) Positive Control; Immunogen; SDS-PAGE; WB.
RPB980Hu02 Recombinant Interleukin 33 (IL33) Positive Control; Immunogen; SDS-PAGE; WB.
APB980Hu01 Active Interleukin 33 (IL33) Cell culture; Activity Assays.
Antibodies PAB980Hu01 Polyclonal Antibody to Interleukin 33 (IL33) WB; IHC; ICC; IP.
MAB980Hu22 Monoclonal Antibody to Interleukin 33 (IL33) WB; IHC
LAB980Hu71 Biotin-Linked Polyclonal Antibody to Interleukin 33 (IL33) WB; IHC; ICC.
PAB980Hu02 Polyclonal Antibody to Interleukin 33 (IL33) WB; IHC; ICC; IP.
MAB980Hu24 Monoclonal Antibody to Interleukin 33 (IL33) WB; IHC; ICC; IP.
MAB980Hu26 Monoclonal Antibody to Interleukin 33 (IL33) WB; IHC; ICC; IP.
LAB980Hu76 Biotin-Linked Monoclonal Antibody to Interleukin 33 (IL33) WB; IHC; ICC.
MAB980Hu21 Monoclonal Antibody to Interleukin 33 (IL33) WB; IHC; ICC; IP.
LAB980Hu72 Biotin-Linked Monoclonal Antibody to Interleukin 33 (IL33) WB; IHC; ICC.
Assay Kits SEB980Hu ELISA Kit for Interleukin 33 (IL33) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB980Hu CLIA Kit for Interleukin 33 (IL33) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB980Mu01 Recombinant Interleukin 33 (IL33) Positive Control; Immunogen; SDS-PAGE; WB.
RPB980Mu02 Recombinant Interleukin 33 (IL33) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB980Mu01 Polyclonal Antibody to Interleukin 33 (IL33) WB; IHC; ICC; IP.
LAB980Mu81 FITC-Linked Polyclonal Antibody to Interleukin 33 (IL33) WB; IHC; ICC; IF.
LAB980Mu71 Biotin-Linked Polyclonal Antibody to Interleukin 33 (IL33) WB; IHC; ICC.
PAB980Mu02 Polyclonal Antibody to Interleukin 33 (IL33) WB; IHC; ICC; IP.
Assay Kits SEB980Mu ELISA Kit for Interleukin 33 (IL33) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB980Mu CLIA Kit for Interleukin 33 (IL33) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB980Ra01 Recombinant Interleukin 33 (IL33) Positive Control; Immunogen; SDS-PAGE; WB.
RPB980Ra02 Recombinant Interleukin 33 (IL33) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB980Ra01 Polyclonal Antibody to Interleukin 33 (IL33) WB; IHC; ICC; IP.
LAB980Ra71 Biotin-Linked Polyclonal Antibody to Interleukin 33 (IL33) WB; IHC; ICC.
PAB980Ra02 Polyclonal Antibody to Interleukin 33 (IL33) WB; IHC; ICC; IP.
MAB980Ra21 Monoclonal Antibody to Interleukin 33 (IL33) WB; IHC; ICC; IP.
MAB980Ra23 Monoclonal Antibody to Interleukin 33 (IL33) WB; IHC; ICC; IP.
MAB980Ra22 Monoclonal Antibody to Interleukin 33 (IL33) WB; IHC; ICC; IP.
Assay Kits SEB980Ra ELISA Kit for Interleukin 33 (IL33) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB980Ra CLIA Kit for Interleukin 33 (IL33) Chemiluminescent immunoassay for Antigen Detection.
  1. "Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules."Am. J. Pathol. 163:69-79(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of genes differentially expressed in canine vasospastic cerebral arteries after subarachnoid hemorrhage."J. Cereb. Blood Flow Metab. 19:1279-1288(1999) [PubMed] [Europe PMC] [Abstract]
  3. "IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines."Immunity 23:479-490(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of constitutively active interleukin 33 (IL-33) splice variant."J. Biol. Chem. 286:20078-20086(2011) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G."Proc. Natl. Acad. Sci. U.S.A. 109:1673-1678(2012) [PubMed] [Europe PMC] [Abstract]
  9. "IL-33 is a chemoattractant for human Th2 cells."Eur. J. Immunol. 37:2779-2786(2007) [PubMed] [Europe PMC] [Abstract]
  10. "IL-33, the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo."Proc. Natl. Acad. Sci. U.S.A. 104:282-287(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Nuclear interleukin-33 is generally expressed in resting endothelium but rapidly lost upon angiogenic or proinflammatory activation."Am. J. Pathol. 173:1229-1242(2008) [PubMed] [Europe PMC] [Abstract]
  12. "The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'?"PLoS ONE 3:E3331-E3331(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Mature interleukin-33 is produced by calpain-mediated cleavage in vivo."Biochem. Biophys. Res. Commun. 387:218-222(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases."Immunity 31:84-98(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Interleukin-33 is biologically active independently of caspase-1 cleavage."J. Biol. Chem. 284:19420-19426(2009) [PubMed] [Europe PMC] [Abstract]
  16. "The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1."Proc. Natl. Acad. Sci. U.S.A. 106:9021-9026(2009) [PubMed] [Europe PMC] [Abstract]
  17. "The dual function cytokine IL-33 interacts with the transcription factor NF-kappaB to dampen NF-kappaB-stimulated gene transcription."J. Immunol. 187:1609-1616(2011) [PubMed] [Europe PMC] [Abstract]
  18. "Interleukin 33 as a mechanically responsive cytokine secreted by living cells."J. Biol. Chem. 287:6941-6948(2012) [PubMed] [Europe PMC] [Abstract]
  19. "Structure of IL-33 and its interaction with the ST2 and IL-1RAcP receptors--insight into heterotrimeric IL-1 signaling complexes."Structure 17:1398-1410(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Structural insights into the interaction of IL-33 with its receptors."Proc. Natl. Acad. Sci. U.S.A. 110:14918-14923(2013) [PubMed] [Europe PMC] [Abstract]