Toll Like Receptor 1 (TLR1)

[Edit]

CD281; TIL; Rsc786; Toll/interleukin-1 receptor-like protein

Toll Like Receptor 1 (TLR1)
TLR 1 is a member of the Toll-like receptor family (TLR) of pattern recognition receptors of the innate immune system. TLR1 recognizes pathogen-associated molecular pattern with a specificity for gram-positive bacteria. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB988Hu01Recombinant Toll Like Receptor 1 (TLR1)SDS-PAGE; WB; ELISA; IP.
RPB988Hu02Recombinant Toll Like Receptor 1 (TLR1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB988Hu01Polyclonal Antibody to Toll Like Receptor 1 (TLR1)WB, ICC, IHC-P, IHC-F, ELISA
MAB988Hu22Monoclonal Antibody to Toll Like Receptor 1 (TLR1)WB, ICC, IHC-P, IHC-F, ELISA
PAB988Hu02Polyclonal Antibody to Toll Like Receptor 1 (TLR1)WB, ICC, IHC-P, IHC-F, ELISA
LAB988Hu71Biotin-Linked Polyclonal Antibody to Toll Like Receptor 1 (TLR1)IHC;WB;ELISA
LAB988Hu81FITC-Linked Polyclonal Antibody to Toll Like Receptor 1 (TLR1)IHC;ICC;IF;WB
MAB988Hu21Monoclonal Antibody to Toll Like Receptor 1 (TLR1)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
Assay KitsSEB988HuELISA Kit for Toll Like Receptor 1 (TLR1)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPB988Mu01Recombinant Toll Like Receptor 1 (TLR1)SDS-PAGE; WB; ELISA; IP.
RPB988Mu02Recombinant Toll Like Receptor 1 (TLR1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAB988Mu01Polyclonal Antibody to Toll Like Receptor 1 (TLR1)WB, ICC, IHC-P, IHC-F, ELISA
PAB988Mu02Polyclonal Antibody to Toll Like Receptor 1 (TLR1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEB988MuELISA Kit for Toll Like Receptor 1 (TLR1)Enzyme-linked immunosorbent assay for Antigen Detection
  1. "A family of human receptors structurally related to Drosophila Toll."Proc. Natl. Acad. Sci. U.S.A. 95:588-593(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Natural selection in the TLR-related genes in the course of primate evolution."Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
  3. "The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes."PLoS ONE 4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract]
  4. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy."J. Immunol. 178:7520-7524(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Structural basis for signal transduction by the Toll/interleukin-1 receptor domains."Nature 408:111-115(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide."Cell 130:1071-1082(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions."J. Infect. Dis. 199:1816-1819(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family."Hum. Mutat. 32:643-652(2011) [PubMed] [Europe PMC] [Abstract]