Interleukin 35 (IL35)
[Edit]Interleukin 35 (IL-35) is an IL-12 family cytokine that is produced by regulatory, but not effector, T cells and plays a role in immune suppression. It is a dimeric protein composed of IL-12alpha; and IL-27beta; chains, which are encoded by two separate genes called IL12A and EBI3, respectively.
Secreted by regulatory T cells (Tregs), IL-35 suppresses inflammatory responses of immune cells. Studies in mice show the absence of either IL-35 chain from regulatory Tregs reduces the cells ability to suppress inflammation; this has been observed during cell culture experiments and using an experimental model for inflammatory bowel disease. To produce its suppressive effects, IL-35 has selective activities on different T cell subsets; it induces proliferation of Treg cell populations but reduces activity of Th17 cell populations.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC008Hu01 | Recombinant Interleukin 35 (IL35) | Positive Control; Immunogen; SDS-PAGE; WB. |
APC008Hu01 | Active Interleukin 35 (IL35) | Cell culture; Activity Assays. | |
Antibodies | PAC008Hu01 | Polyclonal Antibody to Interleukin 35 (IL35) | WB; IHC; ICC; IP. |
MAC008Hu21 | Monoclonal Antibody to Interleukin 35 (IL35) | WB; IHC; ICC; IP. | |
LAC008Hu72 | Biotin-Linked Monoclonal Antibody to Interleukin 35 (IL35) | WB; IHC; ICC. | |
MAC008Hu25 | Monoclonal Antibody to Interleukin 35 (IL35) | WB; IHC; ICC; IP. | |
MAC008Hu22 | Monoclonal Antibody to Interleukin 35 (IL35) | WB; IHC; ICC; IP. | |
MAC008Hu23 | Monoclonal Antibody to Interleukin 35 (IL35) | WB; IHC; ICC; IP. | |
MAC008Hu24 | Monoclonal Antibody to Interleukin 35 (IL35) | WB; IHC; ICC; IP. | |
MAC008Hu27 | Monoclonal Antibody to Interleukin 35 (IL35) | WB; IHC; ICC; IP. | |
Assay Kits | SEC008Hu | ELISA Kit for Interleukin 35 (IL35) | Enzyme-linked immunosorbent assay for Antigen Detection. |
HEC008Hu | High Sensitive ELISA Kit for Interleukin 35 (IL35) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPC008Mu01 | Recombinant Interleukin 35 (IL35) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPC008Mu02 | Recombinant Interleukin 35 (IL35) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAC008Mu01 | Polyclonal Antibody to Interleukin 35 (IL35) | WB; IHC; ICC; IP. |
Assay Kits | SEC008Mu | ELISA Kit for Interleukin 35 (IL35) | Enzyme-linked immunosorbent assay for Antigen Detection. |
SCC008Mu | CLIA Kit for Interleukin 35 (IL35) | Chemiluminescent immunoassay for Antigen Detection. |