Major Histocompatibility Complex Class II DM Beta (MHCDMb)

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RING7; HLA-DMB; HLADMb; HLA Class II Histocompatibility Antigen,DM Beta Chain; Really interesting new gene 7 protein

Major Histocompatibility Complex Class II DM Beta (MHCDMb)

Major histocompatibility complex, class II, DM beta, belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Major Histocompatibility Complex Class II DM Beta (MHCDMb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Major Histocompatibility Complex Class II DM Beta (MHCDMb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Major Histocompatibility Complex Class II DM Beta (MHCDMb) Polyclonal Antibody Customized Service Offer
Assay Kits SEC090Hu ELISA Kit for Major Histocompatibility Complex Class II DM Beta (MHCDMb) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Major Histocompatibility Complex Class II DM Beta (MHCDMb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Major Histocompatibility Complex Class II DM Beta (MHCDMb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Major Histocompatibility Complex Class II DM Beta (MHCDMb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Major Histocompatibility Complex Class II DM Beta (MHCDMb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Major Histocompatibility Complex Class II DM Beta (MHCDMb) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Major Histocompatibility Complex Class II DM Beta (MHCDMb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Major Histocompatibility Complex Class II DM Beta (MHCDMb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Major Histocompatibility Complex Class II DM Beta (MHCDMb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Major Histocompatibility Complex Class II DM Beta (MHCDMb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Major Histocompatibility Complex Class II DM Beta (MHCDMb) ELISA Kit Customized Service Offer
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  2. "Genomic organization of HLA-DMA and HLA-DMB. Comparison of the gene organization of all six class II families in the human major histocompatibility complex."J. Biol. Chem. 269:18834-18838(1994) [PubMed] [Europe PMC] [Abstract]
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  11. "Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM."Science 274:618-620(1996) [PubMed] [Europe PMC] [Abstract]
  12. "Targeting signal and subcellular compartments involved in the intracellular trafficking of HLA-DMB."J. Immunol. 157:1017-1027(1996) [PubMed] [Europe PMC] [Abstract]
  13. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
  14. "The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation."Immunity 9:377-383(1998) [PubMed] [Europe PMC] [Abstract]
  15. "Small molecules that enhance the catalytic efficiency of HLA-DM."J. Immunol. 176:4208-4220(2006) [PubMed] [Europe PMC] [Abstract]