Growth Differentiation Factor 3 (GDF3)

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Vgr2; Vg-Related Gene 2

Growth Differentiation Factor 3 (GDF3)

Growth differentiation factor-3 (GDF3) is protein belonging to the transforming growth factor beta (TGF-beta) superfamily. It has high similarity to other TGF-beta; superfamily members called Vg1 (found in frogs), BMP2, BMP6 and GDF1, but lacks one of the conserved cysteine residues common to all other TGF-beta; superfamily members.Expression of GDF3 occurs in ossifying bone during embryonic development and in the brain, thymus, spleen, bone marrow and adipose tissue of adults.
GDF3 is a bi-functional protein that inhibits some TGF-beta; superfamily members (e.g. BMPs) while activating others, thus regulating the balance between different modes of TGF-beta signaling. It has been shown to negatively and positively control differentiation of embryonic stem cells in mice and humans.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC109Hu01 Recombinant Growth Differentiation Factor 3 (GDF3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC109Hu01 Polyclonal Antibody to Growth Differentiation Factor 3 (GDF3) WB; IHC; ICC; IP.
LAC109Hu71 Biotin-Linked Polyclonal Antibody to Growth Differentiation Factor 3 (GDF3) WB; IHC; ICC.
LAC109Hu81 FITC-Linked Polyclonal Antibody to Growth Differentiation Factor 3 (GDF3) WB; IHC; ICC; IF.
MAC109Hu21 Monoclonal Antibody to Growth Differentiation Factor 3 (GDF3) WB; IHC; ICC; IP.
Assay Kits SEC109Hu ELISA Kit for Growth Differentiation Factor 3 (GDF3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC109Hu CLIA Kit for Growth Differentiation Factor 3 (GDF3) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC109Mu01 Recombinant Growth Differentiation Factor 3 (GDF3) Positive Control; Immunogen; SDS-PAGE; WB.
RPC109Mu02 Recombinant Growth Differentiation Factor 3 (GDF3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC109Mu01 Polyclonal Antibody to Growth Differentiation Factor 3 (GDF3) WB; IHC; ICC; IP.
PAC109Mu02 Polyclonal Antibody to Growth Differentiation Factor 3 (GDF3) WB; IHC; ICC; IP.
Assay Kits SEC109Mu ELISA Kit for Growth Differentiation Factor 3 (GDF3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC109Mu CLIA Kit for Growth Differentiation Factor 3 (GDF3) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC109Ra01 Recombinant Growth Differentiation Factor 3 (GDF3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC109Ra01 Polyclonal Antibody to Growth Differentiation Factor 3 (GDF3) WB; IHC; ICC; IP.
MAC109Ra21 Monoclonal Antibody to Growth Differentiation Factor 3 (GDF3) WB; IHC; ICC; IP.
Assay Kits SEC109Ra ELISA Kit for Growth Differentiation Factor 3 (GDF3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC109Ra CLIA Kit for Growth Differentiation Factor 3 (GDF3) Chemiluminescent immunoassay for Antigen Detection.
  1. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Mutation of the bone morphogenetic protein GDF3 causes ocular and skeletal anomalies."Hum. Mol. Genet. 19:287-298(2010) [PubMed] [Europe PMC] [Abstract]