Growth Differentiation Factor 3 (GDF3)

[Edit]

Vgr2; Vg-Related Gene 2

Growth Differentiation Factor 3 (GDF3)
Growth differentiation factor-3 (GDF3) is protein belonging to the transforming growth factor beta (TGF-β) superfamily. It has high similarity to other TGF-β superfamily members called Vg1 (found in frogs), BMP2, BMP6 and GDF1, but lacks one of the conserved cysteine residues common to all other TGF-β superfamily members.Expression of GDF3 occurs in ossifying bone during embryonic development and in the brain, thymus, spleen, bone marrow and adipose tissue of adults.
GDF3 is a bi-functional protein that inhibits some TGF-β superfamily members (e.g. BMPs) while activating others, thus regulating the balance between different modes of TGF-beta signaling. It has been shown to negatively and positively control differentiation of embryonic stem cells in mice and humans.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPC109Hu01Recombinant Growth Differentiation Factor 3 (GDF3)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAC109Hu01Polyclonal Antibody to Growth Differentiation Factor 3 (GDF3)WB, ICC, IHC-P, IHC-F, ELISA
LAC109Hu71Biotin-Linked Polyclonal Antibody to Growth Differentiation Factor 3 (GDF3)IHC;WB;ELISA
LAC109Hu81FITC-Linked Polyclonal Antibody to Growth Differentiation Factor 3 (GDF3)IHC;ICC;IF;WB
MAC109Hu21Monoclonal Antibody to Growth Differentiation Factor 3 (GDF3)WB; ICC; IHC-P; IHC-F; ELISA; IP; IF; FCM.
Assay KitsSEC109HuELISA Kit for Growth Differentiation Factor 3 (GDF3)Enzyme-linked immunosorbent assay for Antigen Detection
SCC109HuCLIA Kit for Growth Differentiation Factor 3 (GDF3)Chemiluminescent immunoassay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPC109Mu01Recombinant Growth Differentiation Factor 3 (GDF3)SDS-PAGE; WB; ELISA; IP.
RPC109Mu02Recombinant Growth Differentiation Factor 3 (GDF3)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAC109Mu01Polyclonal Antibody to Growth Differentiation Factor 3 (GDF3)WB, ICC, IHC-P, IHC-F, ELISA
PAC109Mu02Polyclonal Antibody to Growth Differentiation Factor 3 (GDF3)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEC109MuELISA Kit for Growth Differentiation Factor 3 (GDF3)Enzyme-linked immunosorbent assay for Antigen Detection
SCC109MuCLIA Kit for Growth Differentiation Factor 3 (GDF3)Chemiluminescent immunoassay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPC109Ra01Recombinant Growth Differentiation Factor 3 (GDF3)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAC109Ra01Polyclonal Antibody to Growth Differentiation Factor 3 (GDF3)WB, ICC, IHC-P, IHC-F, ELISA
MAC109Ra21Monoclonal Antibody to Growth Differentiation Factor 3 (GDF3)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEC109RaELISA Kit for Growth Differentiation Factor 3 (GDF3)Enzyme-linked immunosorbent assay for Antigen Detection
SCC109RaCLIA Kit for Growth Differentiation Factor 3 (GDF3)Chemiluminescent immunoassay for Antigen Detection
  1. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Mutation of the bone morphogenetic protein GDF3 causes ocular and skeletal anomalies."Hum. Mol. Genet. 19:287-298(2010) [PubMed] [Europe PMC] [Abstract]