Growth Differentiation Factor 6 (GDF6)

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BMP13; CDMP2; GDF16; Bone morphogenetic protein 13; Growth/differentiation factor 16

Growth Differentiation Factor 6 (GDF6)

Growth differentiation factor 6 (GDF6) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily of secreted signaling molecules. It is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton.

Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), which is a congenital disorder of spinal segmentation.Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Play a key role in establishing boundaries between skeletal elements during development (By similarity).Defects in GDF6 are associated with Klippel-Feil syndrome (KFS) .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC111Hu01 Recombinant Growth Differentiation Factor 6 (GDF6) Positive Control; Immunogen; SDS-PAGE; WB.
APC111Hu01 Active Growth Differentiation Factor 6 (GDF6) Cell culture; Activity Assays.
Antibodies PAC111Hu01 Polyclonal Antibody to Growth Differentiation Factor 6 (GDF6) WB; IHC; ICC; IP.
MAC111Hu21 Monoclonal Antibody to Growth Differentiation Factor 6 (GDF6) WB; IHC; ICC; IP.
Assay Kits SEC111Hu ELISA Kit for Growth Differentiation Factor 6 (GDF6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC111Mu01 Recombinant Growth Differentiation Factor 6 (GDF6) Positive Control; Immunogen; SDS-PAGE; WB.
APC111Mu01 Active Growth Differentiation Factor 6 (GDF6) Cell culture; Activity Assays.
Antibodies PAC111Mu01 Polyclonal Antibody to Growth Differentiation Factor 6 (GDF6) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Growth Differentiation Factor 6 (GDF6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Differentiation Factor 6 (GDF6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Growth Differentiation Factor 6 (GDF6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Growth Differentiation Factor 6 (GDF6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Growth Differentiation Factor 6 (GDF6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Growth Differentiation Factor 6 (GDF6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Growth Differentiation Factor 6 (GDF6) ELISA Kit Customized Service Offer
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Mutations in GDF6 are associated with vertebral segmentation defects in Klippel-Feil syndrome."Hum. Mutat. 29:1017-1027(2008) [PubMed] [Europe PMC] [Abstract]
  3. "Contribution of growth differentiation factor 6-dependent cell survival to early-onset retinal dystrophies."Hum. Mol. Genet. 22:1432-1442(2013) [PubMed] [Europe PMC] [Abstract]
  4. "Incomplete penetrance and phenotypic variability characterize Gdf6-attributable oculo-skeletal phenotypes." Hum. Mol. Genet. 18:1110-1121(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Mutation of the bone morphogenetic protein GDF3 causes ocular and skeletal anomalies."Hum. Mol. Genet. 19:287-298(2010) [PubMed] [Europe PMC] [Abstract]