Noggin (NOG)

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SYM1; SYNS1; Synostoses(Multiple)Syndrome 1; Symphalangism 1(Proximal)

Noggin (NOG)

Noggin inhibits TGF-beta signal transduction by binding to TGF-beta family ligands and preventing them from binding to their corresponding receptors. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-beta signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development, joint formation, and neural tube fusion.
The secreted polypeptide noggin, encoded by the NOG gene, binds and inactivates members of the transforming TGF-beta superfamily signaling proteins, such as BMP4. By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, noggin may have a principal role in creating morphogenic gradients.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC130Hu01 Recombinant Noggin (NOG) Positive Control; Immunogen; SDS-PAGE; WB.
RPC130Hu02 Recombinant Noggin (NOG) Positive Control; Immunogen; SDS-PAGE; WB.
APC130Hu01 Active Noggin (NOG) Cell culture; Activity Assays.
Antibodies PAC130Hu01 Polyclonal Antibody to Noggin (NOG) WB; IHC; ICC; IP.
MAC130Hu22 Monoclonal Antibody to Noggin (NOG) WB; IHC; ICC; IP.
PAC130Hu02 Polyclonal Antibody to Noggin (NOG) WB; IHC; ICC; IP.
LAC130Hu71 Biotin-Linked Polyclonal Antibody to Noggin (NOG) WB; IHC; ICC.
LAC130Hu81 FITC-Linked Polyclonal Antibody to Noggin (NOG) WB; IHC; ICC; IF.
MAC130Hu24 Monoclonal Antibody to Noggin (NOG) WB; IHC; ICC; IP.
MAC130Hu26 Monoclonal Antibody to Noggin (NOG) WB; IHC; ICC; IP.
LAC130Hu76 Biotin-Linked Monoclonal Antibody to Noggin (NOG) WB; IHC; ICC.
Assay Kits SEC130Mi ELISA Kit for Noggin (NOG) Enzyme-linked immunosorbent assay for Antigen Detection.
HEC130Mi High Sensitive ELISA Kit for Noggin (NOG) Enzyme-linked immunosorbent assay for Antigen Detection.
SEC130Hu ELISA Kit for Noggin (NOG) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC130Mu01 Recombinant Noggin (NOG) Positive Control; Immunogen; SDS-PAGE; WB.
RPC130Mu02 Recombinant Noggin (NOG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC130Mu01 Polyclonal Antibody to Noggin (NOG) WB; IHC; ICC; IP.
PAC130Mu02 Polyclonal Antibody to Noggin (NOG) WB; IHC; ICC; IP.
Assay Kits SEC130Mi ELISA Kit for Noggin (NOG) Enzyme-linked immunosorbent assay for Antigen Detection.
HEC130Mi High Sensitive ELISA Kit for Noggin (NOG) Enzyme-linked immunosorbent assay for Antigen Detection.
SEC130Mu ELISA Kit for Noggin (NOG) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC130Ra01 Recombinant Noggin (NOG) Positive Control; Immunogen; SDS-PAGE; WB.
RPC130Ra02 Recombinant Noggin (NOG) Positive Control; Immunogen; SDS-PAGE; WB.
APC130Ra01 Active Noggin (NOG) Cell culture; Activity Assays.
APC130Ra02 Active Noggin (NOG) Cell culture; Activity Assays.
Antibodies PAC130Ra01 Polyclonal Antibody to Noggin (NOG) WB; IHC; ICC; IP.
PAC130Ra02 Polyclonal Antibody to Noggin (NOG) WB; IHC; ICC; IP.
Assay Kits SEC130Mi ELISA Kit for Noggin (NOG) Enzyme-linked immunosorbent assay for Antigen Detection.
HEC130Mi High Sensitive ELISA Kit for Noggin (NOG) Enzyme-linked immunosorbent assay for Antigen Detection.
SEC130Ra ELISA Kit for Noggin (NOG) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC130Po01 Recombinant Noggin (NOG) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC130Po01 Polyclonal Antibody to Noggin (NOG) WB; IHC; ICC; IP.
LAC130Po71 Biotin-Linked Polyclonal Antibody to Noggin (NOG) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Noggin (NOG) CLIA Kit Customized Service Offer
n/a ELISA Kit for Noggin (NOG) ELISA Kit Customized Service Offer
  1. "Identification of mammalian noggin and its expression in the adult nervous system."J. Neurosci. 15:6077-6084(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance."J. Bone Miner. Res. 27:429-442(2012) [PubMed] [Europe PMC] [Abstract]
  4. "A GDF5 point mutation strikes twice--causing BDA1 and SYNS2."PLoS Genet. 9:E1003846-E1003846(2013) [PubMed] [Europe PMC] [Abstract]
  5. "Structural basis of BMP signalling inhibition by the cystine knot protein Noggin."Nature 420:636-642(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis."Nat. Genet. 21:302-304(1999) [PubMed] [Europe PMC] [Abstract]
  7. "Mutations of the NOG gene in individuals with proximal symphalangism and multiple synostosis syndrome."Clin. Genet. 60:447-451(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Identical mutations in NOG can cause either tarsal/carpal coalition syndrome or proximal symphalangism."Genet. Med. 3:349-353(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Autosomal dominant stapes ankylosis with broad thumbs and toes, hyperopia, and skeletal anomalies is caused by heterozygous nonsense and frameshift mutations in NOG, the gene encoding noggin."Am. J. Hum. Genet. 71:618-624(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of a novel NOG gene mutation (P35S) in an Italian family with symphalangism."Hum. Mutat. 19:308-308(2002) [PubMed] [Europe PMC] [Abstract]
  11. "The facio-audio-symphalangism syndrome in a four generation family with a nonsense mutation in the NOG-gene."Clin. Dysmorphol. 14:73-80(2005) [PubMed] [Europe PMC] [Abstract]
  12. "A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN."Am. J. Hum. Genet. 81:388-396(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Facioaudiosymphalangism syndrome and growth acceleration associated with a heterozygous NOG mutation."Am. J. Med. Genet. A 152:1540-1544(2010) [PubMed] [Europe PMC] [Abstract]