Collagen Type X (COL10)

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COL10A1; COL10-A1; Schmid Metaphyseal Chondrodysplasia; Collagen Alpha-1(X)chain

Collagen Type X (COL10)

Collagen alpha-1(X) chain is the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD).

During development and growth of long bones, chondrocytes pass sequentially through a proliferative, a hypertrophic and a degenerative stage, each characterized by a particular set of collagen types. Proliferative (stage I) chondrocytes synthesize type II collagen as the major collagen and types IX and XI as the minor collagens.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC156Hu01 Recombinant Collagen Type X (COL10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC156Hu01 Polyclonal Antibody to Collagen Type X (COL10) WB; IHC; ICC; IP.
MAC156Hu22 Monoclonal Antibody to Collagen Type X (COL10) WB; IHC; ICC; IP.
LAC156Hu71 Biotin-Linked Polyclonal Antibody to Collagen Type X (COL10) WB; IHC; ICC.
LAC156Hu81 FITC-Linked Polyclonal Antibody to Collagen Type X (COL10) WB; IHC; ICC; IF.
Assay Kits SEC156Hu ELISA Kit for Collagen Type X (COL10) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC156Hu CLIA Kit for Collagen Type X (COL10) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC156Mu01 Recombinant Collagen Type X (COL10) Positive Control; Immunogen; SDS-PAGE; WB.
RPC156Mu02 Recombinant Collagen Type X (COL10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC156Mu01 Polyclonal Antibody to Collagen Type X (COL10) WB; IHC; ICC; IP.
LAC156Mu71 Biotin-Linked Polyclonal Antibody to Collagen Type X (COL10) WB; IHC; ICC.
PAC156Mu02 Polyclonal Antibody to Collagen Type X (COL10) WB; IHC; ICC; IP.
Assay Kits SEC156Mu ELISA Kit for Collagen Type X (COL10) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC156Ra01 Recombinant Collagen Type X (COL10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC156Ra01 Polyclonal Antibody to Collagen Type X (COL10) WB; IHC; ICC; IP.
MAC156Ra21 Monoclonal Antibody to Collagen Type X (COL10) WB; IHC; ICC; IP.
Assay Kits SEC156Ra ELISA Kit for Collagen Type X (COL10) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rhesus monkey (Simian)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC156Si01 Recombinant Collagen Type X (COL10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Collagen Type X (COL10) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Collagen Type X (COL10) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Collagen Type X (COL10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collagen Type X (COL10) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC156Bo01 Recombinant Collagen Type X (COL10) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC156Bo01 Polyclonal Antibody to Collagen Type X (COL10) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Collagen Type X (COL10) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collagen Type X (COL10) ELISA Kit Customized Service Offer
  1. "The human collagen X gene. Complete primary translated sequence and chromosomal localization."Biochem. J. 280:617-623(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Genomic organization and full-length cDNA sequence of human collagen X."FEBS Lett. 311:305-310(1992) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning of the human and mouse type X collagen genes and mapping of the mouse type X collagen gene to chromosome 10."Eur. J. Biochem. 206:217-224(1992) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning of human alpha 1(X) collagen DNA and localization of the COL10A1 gene to the q21-q22 region of human chromosome 6."FEBS Lett. 282:393-396(1991) [PubMed] [Europe PMC] [Abstract]
  7. "In situ hybridization studies on the expression of type X collagen in fetal human cartilage."Dev. Biol. 148:562-572(1991) [PubMed] [Europe PMC] [Abstract]
  8. "Insight into Schmid metaphyseal chondrodysplasia from the crystal structure of the collagen X NC1 domain trimer."Structure 10:165-173(2002) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in fibrillar collagens (types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of diseases of bone, cartilage, and blood vessels."Hum. Mutat. 9:300-315(1997) [PubMed] [Europe PMC] [Abstract]
  10. "Amino acid substitutions of conserved residues in the carboxyl-terminal domain of the alpha 1(X) chain of type X collagen occur in two unrelated families with metaphyseal chondrodysplasia type Schmid."Am. J. Hum. Genet. 54:169-178(1994) [PubMed] [Europe PMC] [Abstract]
  11. "Additional mutations of type X collagen confirm COL10A1 as the Schmid metaphyseal chondrodysplasia locus."Hum. Mol. Genet. 3:303-307(1994) [PubMed] [Europe PMC] [Abstract]
  12. "Type X collagen multimer assembly in vitro is prevented by a Gly618 to Val mutation in the alpha 1(X) NC1 domain resulting in Schmid metaphyseal chondrodysplasia."J. Biol. Chem. 270:4558-4562(1995) [PubMed] [Europe PMC] [Abstract]
  13. "Mutations in three subdomains of the carboxy-terminal region of collagen type X account for most of the Schmid metaphyseal dysplasias."Hum. Genet. 96:58-64(1995) [PubMed] [Europe PMC] [Abstract]
  14. "Mutations within the gene encoding the alpha 1 (X) chain of type X collagen (COL10A1) cause metaphyseal chondrodysplasia type Schmid but not several other forms of metaphyseal chondrodysplasia."J. Med. Genet. 33:450-457(1996) [PubMed] [Europe PMC] [Abstract]
  15. "Mutations in the N-terminal globular domain of the type X collagen gene (COL10A1) in patients with schmid metaphyseal chondrodysplasia."Hum. Mutat. 9:131-135(1997) [PubMed] [Europe PMC] [Abstract]
  16. "Mutation of the type X collagen gene 'COL10A1' causes spondylometaphyseal dysplasia."Am. J. Hum. Genet. 63:1659-1662(1998) [PubMed] [Europe PMC] [Abstract]
  17. "Novel missense mutation resulting in the substitution of tyrosine by cysteine at codon 597 of the type X collagen gene associated with Schmid metaphyseal chondrodysplasia."J. Hum. Genet. 43:259-261(1998) [PubMed] [Europe PMC] [Abstract]
  18. "Mutations of COL10A1 in Schmid metaphyseal chondrodysplasia."Hum. Mutat. 25:525-534(2005) [PubMed] [Europe PMC] [Abstract]