Major Histocompatibility Complex Class II DP Beta 1 (MHCDPb1)

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HLA-DPB1; HLADPb1; HLA-DP1B; MHC-DPB1; HLA Class II Histocompatibility Antigen,DP(W2)Beta Chain

Major Histocompatibility Complex Class II DP Beta 1 (MHCDPb1)

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Major Histocompatibility Complex Class II DP Beta 1 (MHCDPb1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Major Histocompatibility Complex Class II DP Beta 1 (MHCDPb1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Major Histocompatibility Complex Class II DP Beta 1 (MHCDPb1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Major Histocompatibility Complex Class II DP Beta 1 (MHCDPb1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Major Histocompatibility Complex Class II DP Beta 1 (MHCDPb1) ELISA Kit Customized Service Offer
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  50. "Three new DP alleles identified in sub-Saharan Africa: DPB1*7401, DPA1*02013, and DPA1*0302."Tissue Antigens 51:653-657(1998) [PubMed] [Europe PMC] [Abstract]
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