Phosphoinositide Dependent Protein Kinase 1 (PDPK1)

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PDK1; PkB-Like 1

Phosphoinositide Dependent Protein Kinase 1 (PDPK1)
PDPK1 is a master kinase, which is crucial for the activation of AKT/PKB and many other AGC kinases including PKC, S6K, SGK. An important role for PDPK1 is in the signalling pathways activated by several growth factors and hormones including insulin signalling. Mice lacking PDPK1 die during early embryonic development, indicating that this enzyme is critical for transmitting the growth-promoting signals nescessary for normal mammalian development.
Mice that are deficient in PDPK1 have a ≈40% decrease in body mass, mild glucose intolerance, and are resitant to cancer brought about by hyperactivation of the PI3K pathway (PTEN +/-).The structure of PDPK1 can be divided into two domains; the kinase or catalytic domain and the PH domain.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPC246Hu01Recombinant Phosphoinositide Dependent Protein Kinase 1 (PDPK1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAC246Hu01Polyclonal Antibody to Phosphoinositide Dependent Protein Kinase 1 (PDPK1)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Phosphoinositide Dependent Protein Kinase 1 (PDPK1)CLIA Kit Customized Service Offer
n/aELISA Kit for Phosphoinositide Dependent Protein Kinase 1 (PDPK1)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPC246Mu01Recombinant Phosphoinositide Dependent Protein Kinase 1 (PDPK1)SDS-PAGE; WB; ELISA; IP.
RPC246Mu02Recombinant Phosphoinositide Dependent Protein Kinase 1 (PDPK1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAC246Mu01Polyclonal Antibody to Phosphoinositide Dependent Protein Kinase 1 (PDPK1)WB, ICC, IHC-P, IHC-F, ELISA
PAC246Mu02Polyclonal Antibody to Phosphoinositide Dependent Protein Kinase 1 (PDPK1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEC246MuELISA Kit for Phosphoinositide Dependent Protein Kinase 1 (PDPK1)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Phosphoinositide Dependent Protein Kinase 1 (PDPK1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Phosphoinositide Dependent Protein Kinase 1 (PDPK1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Phosphoinositide Dependent Protein Kinase 1 (PDPK1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Phosphoinositide Dependent Protein Kinase 1 (PDPK1)CLIA Kit Customized Service Offer
n/aELISA Kit for Phosphoinositide Dependent Protein Kinase 1 (PDPK1)ELISA Kit Customized Service Offer
  1. "Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha."Curr. Biol. 7:261-269(1997) [PubMed] [Europe PMC] [Abstract]
  2. "3-phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase."Curr. Biol. 7:776-789(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B."Science 279:710-714(1998) [PubMed] [Europe PMC] [Abstract]
  4. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]