Fusion (FUS)

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CHOP; ALS6; TLS; hnRNP-P2; Amyotrophic Lateral Sclerosis 6; Heterogeneous Nuclear Ribonucleoprotein P2; 75 kDa DNA-pairing protein; Translocated in liposarcoma protein

Fusion (FUS)
FUS is a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. The N-terminal end of FUS appears to be involved in transcriptional activation, while the C-terminal end is involved in protein and RNA binding. In addition recognition sites for the transcription factors AP2, GCF, Sp1 have been identified in FUS.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPC260Hu01Recombinant Fusion (FUS)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAC260Hu01Polyclonal Antibody to Fusion (FUS)WB, ICC, IHC-P, IHC-F, ELISA
MAC260Hu22Monoclonal Antibody to Fusion (FUS)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEC260HuELISA Kit for Fusion (FUS)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPC260Mu01Recombinant Fusion (FUS)SDS-PAGE; WB; ELISA; IP.
RPC260Mu02Recombinant Fusion (FUS)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAC260Mu01Polyclonal Antibody to Fusion (FUS)WB, ICC, IHC-P, IHC-F, ELISA
LAC260Mu81FITC-Linked Polyclonal Antibody to Fusion (FUS)IHC;ICC;IF;WB
LAC260Mu71Biotin-Linked Polyclonal Antibody to Fusion (FUS)IHC;WB;ELISA
PAC260Mu02Polyclonal Antibody to Fusion (FUS)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEC260MuELISA Kit for Fusion (FUS)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Fusion (FUS)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Fusion (FUS)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Fusion (FUS)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Fusion (FUS)CLIA Kit Customized Service Offer
n/aELISA Kit for Fusion (FUS)ELISA Kit Customized Service Offer
  1. "Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma."Nature 363:640-644(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma."Nat. Genet. 4:175-180(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes."Gene 221:191-198(1998) [PubMed] [Europe PMC] [Abstract]
  4. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF-1 genes induced by a chromosomal translocation involving bands 12q13 and 16p11."Cancer Genet. Cytogenet. 121:109-116(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation."J. Biol. Chem. 274:34337-34342(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Human POMp75 is identified as the pro-oncoprotein TLF/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation."Oncogene 18:4515-4521(1999) [PubMed] [Europe PMC] [Abstract]