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11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1)

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11DH; 11-beta-HSD1; HDL; HSD11; HSD11B; HSD11L; SDR26C1; Corticosteroid 11-beta-dehydrogenase isozyme 1; Short Chain Dehydrogenase/Reductase Family 26C,Member 1

11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1)
CCC C268
HGNC 5208
MGI 103562
PubMed 21622477
RGD 2834
UniProt P28845
Wiki HSD11B1

11b-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system. In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors. It is inhibited by carbenoxolone, a drug typically used in the treatment of peptic ulcers. The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC268Hu01 Recombinant 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC268Hu01 Polyclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) WB; IHC; ICC; IP.
MAC268Hu22 Monoclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) WB; IHC; ICC; IP.
Assay Kits SEC268Hu ELISA Kit for 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC268Mu01 Recombinant 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) Polyclonal Antibody Customized Service Offer
Assay Kits SEC268Mu ELISA Kit for 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC268Ra01 Recombinant 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC268Ra01 Polyclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) WB; IHC; ICC; IP.
MAC268Ra21 Monoclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) WB; IHC; ICC; IP.
Assay Kits SEC268Ra ELISA Kit for 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1) Enzyme-linked immunosorbent assay for Antigen Detection.
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