≡

Calcium Binding Protein P22 (CHP)

[Edit]

SLC9A1BP; Calcineurin homologous protein; Calcineurin B-like protein; EF-hand calcium-binding domain-containing protein p22

Calcium Binding Protein P22 (CHP)
CCC C378
MGI 1927185
PubMed 10512881
RGD 620447
UniProt Q99653
Wiki CHP

Calcium binding protein P22 is a phosphoprotein that binds to the sodium-potassium exchangers (NHEs). This protein serves as an essential cofactor which supports the physiological activity of NHE family members. It has protein sequence similarity to calcineurin B and it is also known to be an endogenous inhibitor of calcineurin activity.

A partial sequence obtained from this screen was used to clone a novel full-length cDNA, designated CHP, from a second B-cell library. The deduced 195-amino acid protein contains 2 distinct and 2 potential EF-hand Ca(2+)-binding motifs and shares 43% and 33% identity with calcineurin B and calmodulin, respectively. It also shares 99% sequence identity with the rat homolog. Northern blot analysis demonstrated expression of a 4-kb CHP transcript in all 8 fetal tissues examined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC378Hu01 Recombinant Calcium Binding Protein P22 (CHP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC378Hu01 Polyclonal Antibody to Calcium Binding Protein P22 (CHP) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Calcium Binding Protein P22 (CHP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Binding Protein P22 (CHP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Binding Protein P22 (CHP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Binding Protein P22 (CHP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Binding Protein P22 (CHP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Binding Protein P22 (CHP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Binding Protein P22 (CHP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Calcium Binding Protein P22 (CHP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Calcium Binding Protein P22 (CHP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Calcium Binding Protein P22 (CHP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Calcium Binding Protein P22 (CHP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Calcium Binding Protein P22 (CHP) ELISA Kit Customized Service Offer
  1. "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange."Proc. Natl. Acad. Sci. U.S.A. 93:12631-12636(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Inhibition of calcineurin phosphatase activity by a calcineurin B homologous protein."J. Biol. Chem. 274:36125-36131(1999) [PubMed] [Europe PMC] [Abstract]
  5. "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers."J. Biol. Chem. 276:17367-17372(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Role of calcineurin B homologous protein in pH regulation by the Na+/H+ exchanger 1: tightly bound Ca2+ ions as important structural elements."Biochemistry 43:3628-3636(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Nuclear-localized calcineurin homologous protein CHP1 interacts with upstream binding factor and inhibits ribosomal RNA synthesis."J. Biol. Chem. 285:36260-36266(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1."J. Biol. Chem. 282:2741-2751(2007) [PubMed] [Europe PMC] [Abstract]