Cardiotrophin Like Cytokine Factor 1 (CLCF1)

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CLC; NR6; BSF3; CISS2; NNT1; Novel Neurotrophin-1; B Cell-Stimulating Factor-3

Cardiotrophin Like Cytokine Factor 1 (CLCF1)

IL6 family members share similarity in gene structure and have a 4-helix bundle in their protein structure. CLCF1 is closely related to other proteins called cardiotrophin-1 and ciliary neurotrophic factor.
CLCF1 induces tyrosine phosphorylation of the IL-6 receptor common subunit glycoprotein 130 (gp130), leukemia inhibitory factor receptor beta, and the transcription factor STAT3. It has been implicated in the induction of IL-1 (via induction of corticosterone and IL-6) and serum amyloid A, and in B cell hyperplasia. This cytokine is capable of B cell activation via gp130 receptor stimulation.The term "neurotrophin" is commonly used to refer collectively to the four structurally related factors NGF, BDNF, NT-3 and NT-4, while NNT1 bears no structural resemblance to these four proteins.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPC389Hu01Recombinant Cardiotrophin Like Cytokine Factor 1 (CLCF1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAC389Hu01Polyclonal Antibody to Cardiotrophin Like Cytokine Factor 1 (CLCF1)WB, ICC, IHC-P, IHC-F, ELISA
MAC389Hu22Monoclonal Antibody to Cardiotrophin Like Cytokine Factor 1 (CLCF1)WB, ICC, IHC-P, IHC-F, ELISA
LAC389Hu71Biotin-Linked Polyclonal Antibody to Cardiotrophin Like Cytokine Factor 1 (CLCF1)IHC;WB;ELISA
Assay KitsSEC389HuELISA Kit for Cardiotrophin Like Cytokine Factor 1 (CLCF1)Enzyme-linked immunosorbent assay
SCC389HuCLIA Kit for Cardiotrophin Like Cytokine Factor 1 (CLCF1)Chemiluminescent immunoassay

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPC389Mu01Recombinant Cardiotrophin Like Cytokine Factor 1 (CLCF1)SDS-PAGE; WB; ELISA; IP.
RPC389Mu02Recombinant Cardiotrophin Like Cytokine Factor 1 (CLCF1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAC389Mu01Polyclonal Antibody to Cardiotrophin Like Cytokine Factor 1 (CLCF1)WB, ICC, IHC-P, IHC-F, ELISA
PAC389Mu02Polyclonal Antibody to Cardiotrophin Like Cytokine Factor 1 (CLCF1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEC389MuELISA Kit for Cardiotrophin Like Cytokine Factor 1 (CLCF1)Enzyme-linked immunosorbent assay
SCC389MuCLIA Kit for Cardiotrophin Like Cytokine Factor 1 (CLCF1)Chemiluminescent immunoassay

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPC389Ra01Recombinant Cardiotrophin Like Cytokine Factor 1 (CLCF1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAC389Ra01Polyclonal Antibody to Cardiotrophin Like Cytokine Factor 1 (CLCF1)WB, ICC, IHC-P, IHC-F, ELISA
MAC389Ra21Monoclonal Antibody to Cardiotrophin Like Cytokine Factor 1 (CLCF1)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEC389RaELISA Kit for Cardiotrophin Like Cytokine Factor 1 (CLCF1)Enzyme-linked immunosorbent assay
SCC389RaCLIA Kit for Cardiotrophin Like Cytokine Factor 1 (CLCF1)Chemiluminescent immunoassay
  1. "Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family."Proc. Natl. Acad. Sci. U.S.A. 96:11458-11463(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Computational EST database analysis identifies a novel member of the neuropoietic cytokine family."Biochem. Biophys. Res. Commun. 262:132-138(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient."Proc. Natl. Acad. Sci. U.S.A. 103:10068-10073(2006) [PubMed] [Europe PMC] [Abstract]