Corticotropin Releasing Hormone Binding Protein (CRHBP)

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CRF-BP; CRFBP; Corticotropin-Releasing Factor-Binding Protein

Corticotropin Releasing Hormone Binding Protein (CRHBP)

Corticotropin-releasing factor-binding protein is a protein encoded by the CRHBP gene.Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition.

Potter et al. (1991) isolated and partially purified the binding protein and cloned and characterized its cDNA from human liver and rat brain. Expression of the cDNAs in COS-7 cells showed that the protein binds CRH with the same affinity as the native protein. Furthermore, the recombinant binding protein inhibited CRH binding to a CRH antibody and inhibited CRH-induced release of ACTH by pituitary cells in vitro.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC401Hu01 Recombinant Corticotropin Releasing Hormone Binding Protein (CRHBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC401Hu01 Polyclonal Antibody to Corticotropin Releasing Hormone Binding Protein (CRHBP) WB; IHC; ICC; IP.
MAC401Hu22 Monoclonal Antibody to Corticotropin Releasing Hormone Binding Protein (CRHBP) WB; IHC; ICC; IP.
Assay Kits SEC401Hu ELISA Kit for Corticotropin Releasing Hormone Binding Protein (CRHBP) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Corticotropin Releasing Hormone Binding Protein (CRHBP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Corticotropin Releasing Hormone Binding Protein (CRHBP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Corticotropin Releasing Hormone Binding Protein (CRHBP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Corticotropin Releasing Hormone Binding Protein (CRHBP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Corticotropin Releasing Hormone Binding Protein (CRHBP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC401Ra01 Recombinant Corticotropin Releasing Hormone Binding Protein (CRHBP) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC401Ra01 Polyclonal Antibody to Corticotropin Releasing Hormone Binding Protein (CRHBP) WB; IHC; ICC; IP.
MAC401Ra21 Monoclonal Antibody to Corticotropin Releasing Hormone Binding Protein (CRHBP) WB
LAC401Ra71 Biotin-Linked Polyclonal Antibody to Corticotropin Releasing Hormone Binding Protein (CRHBP) WB; IHC; ICC.
MAC401Ra22 Monoclonal Antibody to Corticotropin Releasing Hormone Binding Protein (CRHBP) WB
Assay Kits SEC401Ra ELISA Kit for Corticotropin Releasing Hormone Binding Protein (CRHBP) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins."Nature 349:423-426(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Assignment of disulfide bonds in corticotropin-releasing factor-binding protein."J. Biol. Chem. 269:4313-4316(1994) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP)."Genomics 16:63-68(1993) [PubMed] [Europe PMC] [Abstract]