Cylindromatosis (CYLD)

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CDMT; CYLD1; CYLDI; EAC; USPL2; Turban Tumor Syndrome; Ubiquitin Carboxyl-Terminal Hydrolase CYLD; Ubiquitin Specific Peptidase Like 2; Deubiquitinating enzyme CYLD

Cylindromatosis (CYLD)
Cylindromatosis (turban tumor syndrome), also known as CYLD, encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. The CYLD protein has 3 cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains, which are found in proteins that coordinate the attachment of organelles to microtubules. CYLD also has sequence homology to the catalytic domain of ubiquitin carboxy-terminal hydrolases. RT-PCR detected expression of CYLD in fetal brain, testis, and skeletal muscle, and at a lower level in adult brain, leukocytes, liver, heart, kidney, spleen, ovary, and lung. The splice variant lacking exon 7 was found in all tissues in which CYLD was expressed except kidney.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPC423Hu01Recombinant Cylindromatosis (CYLD)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAC423Hu01Polyclonal Antibody to Cylindromatosis (CYLD)WB, ICC, IHC-P, IHC-F, ELISA
MAC423Hu22Monoclonal Antibody to Cylindromatosis (CYLD)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEC423HuELISA Kit for Cylindromatosis (CYLD)Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Cylindromatosis (CYLD)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Cylindromatosis (CYLD)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Cylindromatosis (CYLD)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Cylindromatosis (CYLD)CLIA Kit Customized Service Offer
n/aELISA Kit for Cylindromatosis (CYLD)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Cylindromatosis (CYLD)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Cylindromatosis (CYLD)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Cylindromatosis (CYLD)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Cylindromatosis (CYLD)CLIA Kit Customized Service Offer
n/aELISA Kit for Cylindromatosis (CYLD)ELISA Kit Customized Service Offer
  1. "Identification of the familial cylindromatosis tumor suppressor gene." Nat. Genet. 25:160-165(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  6. "CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members."Nature 424:793-796(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB."Nature 424:797-801(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination."Nature 424:801-805(2003) [PubMed] [Europe PMC] [Abstract]
  9. "The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor."J. Exp. Med. 198:1959-1964(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation."Mol. Cell. Biol. 25:3886-3895(2005) [PubMed] [Europe PMC] [Abstract]
  11. "The tumor suppressor CYLD regulates entry into mitosis."Proc. Natl. Acad. Sci. U.S.A. 104:8869-8874(2007) [PubMed] [Europe PMC] [Abstract]
  12. "The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response."EMBO Rep. 9:930-936(2008) [PubMed] [Europe PMC] [Abstract]
  13. "The tumor suppressor CYLD regulates microtubule dynamics and plays a role in cell migration."J. Biol. Chem. 283:8802-8809(2008) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "CYLD regulates angiogenesis by mediating vascular endothelial cell migration."Blood 115:4130-4137(2010) [PubMed] [Europe PMC] [Abstract]
  16. "CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin."EMBO J. 29:131-144(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl."Mol. Cell 37:607-619(2010) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells."Nat. Commun. 5:4585-4585(2014) [PubMed] [Europe PMC] [Abstract]
  20. "The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma." Structure 12:1719-1728(2004) [PubMed] [Europe PMC] [Abstract]
  21. "Solution structure of the 1st and 2nd CAP-Gly domains in human cylindromatosis tumor suppressor CYLD."Submitted (NOV-2004) to the PDB data bank
  22. "Phenotype diversity in familial cylindromatosis: a frameshift mutation in the tumor suppressor gene CYLD underlies different tumors of skin appendages."J. Invest. Dermatol. 119:527-531(2002) [PubMed] [Europe PMC] [Abstract]
  23. "Identification of a recurrent mutation in the CYLD gene in Brooke-Spiegler syndrome."Clin. Exp. Dermatol. 28:539-541(2003) [PubMed] [Europe PMC] [Abstract]
  24. "The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module."Mol. Cell 29:451-464(2008) [PubMed] [Europe PMC] [Abstract]
  25. "A novel missense mutation in CYLD in a family with Brooke-Spiegler syndrome."J. Invest. Dermatol. 121:732-734(2003) [PubMed] [Europe PMC] [Abstract]
  26. "Two novel CYLD gene mutations in Chinese families with trichoepithelioma and a literature review of 16 families with trichoepithelioma reported in China."Br. J. Dermatol. 153:1213-1215(2005) [PubMed] [Europe PMC] [Abstract]
  27. "Mutations in the CYLD gene in Brooke-Spiegler syndrome, familial cylindromatosis, and multiple familial trichoepithelioma: lack of genotype-phenotype correlation."J. Invest. Dermatol. 124:919-920(2005) [PubMed] [Europe PMC] [Abstract]
  28. "CYLD mutations underlie Brooke-Spiegler, familial cylindromatosis, and multiple familial trichoepithelioma syndromes."Clin. Genet. 70:246-249(2006) [PubMed] [Europe PMC] [Abstract]