Hepatic Leukemia Factor (HLF)
Hepatic leukemia factor is a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
The predicted HLF protein contains 295 amino acids and has a calculated molecular mass of 33.3 kD. In vitro transcription and translation yielded a protein of about 43 kD.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Hepatic Leukemia Factor (HLF)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Hepatic Leukemia Factor (HLF)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Hepatic Leukemia Factor (HLF)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Hepatic Leukemia Factor (HLF)CLIA Kit Customized Service Offer
n/aELISA Kit for Hepatic Leukemia Factor (HLF)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Hepatic Leukemia Factor (HLF)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Hepatic Leukemia Factor (HLF)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Hepatic Leukemia Factor (HLF)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Hepatic Leukemia Factor (HLF)CLIA Kit Customized Service Offer
n/aELISA Kit for Hepatic Leukemia Factor (HLF)ELISA Kit Customized Service Offer
  1. "Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia."Genes Dev. 6:1608-1620(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia."Science 257:531-534(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]