Keratocan (KERA)
[Edit]CNA2; SLRR2B; Keratocan Proteoglycan; Keratan sulfate proteoglycan keratocan
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Keratocan is a protein encoded by the KERA gene.Keratan sulfate proteoglycans (KSPGs) are members of the small leucine-rich proteoglycan (SLRP) family. KSPGs, particularly keratocan, lumican, and mimecan , are important to the transparency of the cornea.
Defects in KERA are the cause of the autosomal recessive cornea plana 2 (CNA2). In CNA2, the forward convex curvature is flattened, leading to a decrease in refraction, reduced visual activity, extreme hyperopia (usually plus 10 d or more), hazy corneal limbus, opacities in the corneal parenchyma, and marked arcus senilis (often detected at an early age). CNA2 is a rare disorder with a worldwide distribution, but a high prevalence in the Finnish population.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC553Hu01 | Recombinant Keratocan (KERA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC553Hu01 | Polyclonal Antibody to Keratocan (KERA) | WB; IHC; ICC; IP. |
| MAC553Hu22 | Monoclonal Antibody to Keratocan (KERA) | WB; IHC; ICC; IP. | |
| Assay Kits | SEC553Hu | ELISA Kit for Keratocan (KERA) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC553Mu01 | Recombinant Keratocan (KERA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC553Mu01 | Polyclonal Antibody to Keratocan (KERA) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Keratocan (KERA) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Keratocan (KERA) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Keratocan (KERA) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Keratocan (KERA) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Keratocan (KERA) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Keratocan (KERA) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Keratocan (KERA) | ELISA Kit Customized Service Offer |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPC553Bo01 | Recombinant Keratocan (KERA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAC553Bo01 | Polyclonal Antibody to Keratocan (KERA) | WB; IHC; ICC; IP. |
| Assay Kits | n/a | CLIA Kit for Keratocan (KERA) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Keratocan (KERA) | ELISA Kit Customized Service Offer |
- "Structure and sequence of the gene encoding human keratocan."DNA Seq. 10:67-74(1999) [PubMed] [Europe PMC] [Abstract]
- "Mutations in KERA, encoding keratocan, cause cornea plana."Nat. Genet. 25:91-95(2000) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Keratocan expression is increased in the stroma of keratoconus corneas."Mol. Med. 7:470-477(2001) [PubMed] [Europe PMC] [Abstract]
- "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
- "A novel keratocan mutation causing autosomal recessive cornea plana."Invest. Ophthalmol. Vis. Sci. 42:3118-3122(2001) [PubMed] [Europe PMC] [Abstract]