L-Plastin (LCP1)

[Edit]

CP64; LC64P; PLS2; Lymphocyte Cytosolic Protein 1; Plastin 2

L-Plastin (LCP1)

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.).

L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC561Hu01 Recombinant L-Plastin (LCP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC561Hu01 Polyclonal Antibody to L-Plastin (LCP1) WB; IHC
MAC561Hu22 Monoclonal Antibody to L-Plastin (LCP1) WB; IHC; ICC; IP.
Assay Kits SEC561Hu ELISA Kit for L-Plastin (LCP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant L-Plastin (LCP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to L-Plastin (LCP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to L-Plastin (LCP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for L-Plastin (LCP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for L-Plastin (LCP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant L-Plastin (LCP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to L-Plastin (LCP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to L-Plastin (LCP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for L-Plastin (LCP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for L-Plastin (LCP1) ELISA Kit Customized Service Offer
  1. "65-kilodalton protein phosphorylated by interleukin 2 stimulation bears two putative actin-binding sites and two calcium-binding sites."Biochemistry 29:8319-8324(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts."Mol. Cell. Biol. 8:4659-4668(1988) [PubMed] [Europe PMC] [Abstract]
  6. "Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain."Mol. Cell. Biol. 10:1818-1821(1990) [PubMed] [Europe PMC] [Abstract]
  7. , Submitted (MAY-2006) to UniProtKB
  8. "Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells."J. Biol. Chem. 268:2781-2792(1993) [PubMed] [Europe PMC] [Abstract]
  9. "Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells."Biochemistry 29:1055-1062(1990) [PubMed] [Europe PMC] [Abstract]
  10. "Purification and characterization of a cytosolic 65-kilodalton phosphoprotein in human leukocytes whose phosphorylation is augmented by stimulation with interleukin 1."Biochemistry 27:3765-3770(1988) [PubMed] [Europe PMC] [Abstract]
  11. "Nonrandom fusion of L-plastin(LCP1) and LAZ3(BCL6) genes by t(3;13)(q27;q14) chromosome translocation in two cases of B-cell non-Hodgkin lymphoma."Genes Chromosomes Cancer 26:97-105(1999) [PubMed] [Europe PMC] [Abstract]
  12. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Phosphorylation on Ser5 increases the F-actin-binding activity of L-plastin and promotes its targeting to sites of actin assembly in cells."J. Cell Sci. 119:1947-1960(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Costimulation induced phosphorylation of L-plastin facilitates surface transport of the T cell activation molecules CD69 and CD25."Eur. J. Immunol. 37:649-662(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Solution structure of the fourth CH domain from human L-plastin."Submitted (JUN-2006) to the PDB data bank