Loricrin (LOR)
Loricrin is a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in this gene are associated with Vohwinkel's syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases.
There were multiple sequence variants within these 2 size class alleles due to various deletions of 12 bp (4 amino acids) in the major loop of this glycine loop domain. By use of a specific loricrin antibody in immunogold electron microscopy, they showed that loricrin appears initially in the granular layer of human epidermis and forms composite keratohyalin granules with profilaggrin, but localizes to the cell periphery (cell envelope) of fully differentiated stratum corneum cells.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPC568Hu01Recombinant Loricrin (LOR)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAC568Hu01Polyclonal Antibody to Loricrin (LOR)WB, ICC, IHC-P, IHC-F, ELISA
MAC568Hu22Monoclonal Antibody to Loricrin (LOR)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEC568HuELISA Kit for Loricrin (LOR)Enzyme-linked immunosorbent assay

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Loricrin (LOR)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Loricrin (LOR)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Loricrin (LOR)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Loricrin (LOR)CLIA Kit Customized Service Offer
n/aELISA Kit for Loricrin (LOR)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Loricrin (LOR)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Loricrin (LOR)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Loricrin (LOR)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Loricrin (LOR)CLIA Kit Customized Service Offer
n/aELISA Kit for Loricrin (LOR)ELISA Kit Customized Service Offer
  1. "Characterization of human loricrin. Structure and function of a new class of epidermal cell envelope proteins."J. Biol. Chem. 266:6626-6636(1991) [PubMed] [Europe PMC] [Abstract]
  2. "The human loricrin gene."J. Biol. Chem. 267:18060-18066(1992) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The molecular pathology of progressive symmetric erythrokeratoderma: a frameshift mutation in the loricrin gene and perturbations in the cornified cell envelope."Am. J. Hum. Genet. 61:581-589(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Transglutaminase cross-linking properties of the small proline-rich 1 family of cornified cell envelope proteins. Integration with loricrin."J. Biol. Chem. 274:7226-7237(1999) [PubMed] [Europe PMC] [Abstract]
  7. "A recurrent mutation in the loricrin gene underlies the ichthyotic variant of Vohwinkel syndrome."Clin. Exp. Dermatol. 27:243-246(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Loricrin keratoderma: a novel disease entity characterized by nuclear accumulation of mutant loricrin."J. Dermatol. Sci. 31:3-8(2003) [PubMed] [Europe PMC] [Abstract]