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Nucleophosmin 1 (NPM1)

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B23; NPM; Nucleolar Phosphoprotein B23; Numatrin; Nucleophosmin/Nucleoplasmin Family,Member 1; Nucleolar protein NO38

Nucleophosmin 1 (NPM1)
CCC C664
HGNC 7910
MGI 3647121
PubMed 16794633
RGD 3192
UniProt P06748
Wiki NPM1

NPM1 is associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. It may be involved in the assembly and/or transport of ribosome. Its regulation through SUMOylation (by SENP3 and SENP5) is another facet of the proteins's regulation and cellular functions. It is located in nucleolus, but it can be translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. The protein is phosphorylated.

Chromosomal aberrations involving NPM1 were found in patients with non-Hodgkin lymphoma, acute promyelocytic leukemia, myelodysplastic syndrome, and acute myelogenous leukemia.It has been found in the cytoplasm in patients with primary acute myelogenous leukemia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC664Hu01 Recombinant Nucleophosmin 1 (NPM1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC664Hu02 Recombinant Nucleophosmin 1 (NPM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC664Hu01 Polyclonal Antibody to Nucleophosmin 1 (NPM1) WB; IHC; ICC; IP.
MAC664Hu22 Monoclonal Antibody to Nucleophosmin 1 (NPM1) WB; IHC; ICC; IP.
PAC664Hu02 Polyclonal Antibody to Nucleophosmin 1 (NPM1) WB; IHC; ICC; IP.
LAC664Hu71 Biotin-Linked Polyclonal Antibody to Nucleophosmin 1 (NPM1) WB; IHC; ICC.
Assay Kits SEC664Hu ELISA Kit for Nucleophosmin 1 (NPM1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC664Mu01 Recombinant Nucleophosmin 1 (NPM1) Positive Control; Immunogen; SDS-PAGE; WB.
RPC664Mu02 Recombinant Nucleophosmin 1 (NPM1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC664Mu01 Polyclonal Antibody to Nucleophosmin 1 (NPM1) WB; IHC; ICC; IP.
PAC664Mu02 Polyclonal Antibody to Nucleophosmin 1 (NPM1) WB,IHC,ICC/IF
LAC664Mu71 Biotin-Linked Polyclonal Antibody to Nucleophosmin 1 (NPM1) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Nucleophosmin 1 (NPM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleophosmin 1 (NPM1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleophosmin 1 (NPM1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleophosmin 1 (NPM1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleophosmin 1 (NPM1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleophosmin 1 (NPM1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleophosmin 1 (NPM1) ELISA Kit Customized Service Offer
  1. "Characterization of the cDNA encoding human nucleophosmin and studies of its role in normal and abnormal growth."Biochemistry 28:1033-1039(1989) [PubMed] [Europe PMC] [Abstract]
  2. "The nucleotide sequence of a human cDNA encoding the highly conserved nucleolar phosphoprotein B23."Biochem. Biophys. Res. Commun. 163:72-78(1989) [PubMed] [Europe PMC] [Abstract]
  3. "Isolation and characterization of a molecular cDNA clone of a human mRNA from interferon-treated cells encoding nucleolar protein B23, numatrin."Biochem. Biophys. Res. Commun. 164:176-184(1989) [PubMed] [Europe PMC] [Abstract]
  4. "Isolation and characterization of the human nucleophosmin/B23 (NPM) gene: identification of the YY1 binding site at the 5' enhancer region."Nucleic Acids Res. 25:1225-1232(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype." N. Engl. J. Med. 352:254-266(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Cytoplasmic nucleophosmin in myeloid sarcoma occurring 20 years after diagnosis of acute myeloid leukaemia."Lancet Oncol. 7:350-352(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion."Blood 87:882-886(1996) [PubMed] [Europe PMC] [Abstract]
  11. "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma."Science 263:1281-1284(1994) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)."Proc. Natl. Acad. Sci. U.S.A. 93:4181-4186(1996) [PubMed] [Europe PMC] [Abstract]