Polymerase DNA Directed Alpha 1 (POLa1)

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POLA; p180; DNA polymerase alpha catalytic subunit p180

Polymerase DNA Directed Alpha 1 (POLa1)
Hanaoka et al. (1985) complemented a temperature-sensitive defect in murine POLA by fusing the defective mouse cells with human cells. A gene present on Xpter-q22 was responsible for correcting the defect. Wang et al. (1985) used a monoclonal antibody that distinguishes human from rodent DNA polymerase alpha to study human-rodent cell hybrids. They mapped the gene to a site near the junction of Xp21.3 and Xp22.1 (perhaps Xp21.12-p21.11) and showed that it is not expressed in an inactive X chromosome. They concluded that POLA is distal to DMD and CGD but proximal to STS. They predicted that mosaic nullisomy in a female resulting from deletion of this gene could not exist and that hemizygosity for deletion of the gene in a male would be lethal because of the essentiality of the gene to the catalytic activity of DNA polymerase alpha.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC713Hu01 Recombinant Polymerase DNA Directed Alpha 1 (POLa1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC713Hu01 Polyclonal Antibody to Polymerase DNA Directed Alpha 1 (POLa1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Polymerase DNA Directed Alpha 1 (POLa1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polymerase DNA Directed Alpha 1 (POLa1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC713Mu01 Recombinant Polymerase DNA Directed Alpha 1 (POLa1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC713Mu01 Polyclonal Antibody to Polymerase DNA Directed Alpha 1 (POLa1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Polymerase DNA Directed Alpha 1 (POLa1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Polymerase DNA Directed Alpha 1 (POLa1) ELISA Kit Customized Service Offer
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