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Rhodopsin (RHO)

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OPN2; RP4; Opsin 2; Rod Pigment; Retinitis Pigmentosa 4; Visual Purple

Rhodopsin (RHO)
CCC C777
HGNC 10012
MGI 97914
PubMed 11581499
RGD 3573
UniProt P08100
Wiki Rhodopsin
Rhodopsin is a pigment of the retina that is responsible for both the formation of the photoreceptor cells and the first events in the perception of light. Rhodopsins belong to the G-protein coupled receptor family and are extremely sensitive to light, enabling vision in low-light conditions. Exposed to light, the pigment immediately photobleaches, and it takes about 30 minutes to regenerate fully in humans.Rhodopsin consists of the protein moiety opsin and a reversibly covalently bound cofactor, retinal. Opsin, a bundle of seven transmembrane helices, binds retinal, a photoreactive chromophore, in a central pocket. Retinal is produced in the retina from Vitamin A. Isomerization of 11-cis-retinal into all-trans-retinal by light induces a conformational change in opsin that activates the associated G protein and triggers a second messenger cascade.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC777Hu01 Recombinant Rhodopsin (RHO) Positive Control; Immunogen; SDS-PAGE; WB.
RPC777Hu02 Recombinant Rhodopsin (RHO) Positive Control; Immunogen; SDS-PAGE; WB.
RPC777Hu03 Recombinant Rhodopsin (RHO) Positive Control; Immunogen; SDS-PAGE; WB.
RPC777Hu04 Recombinant Rhodopsin (RHO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC777Hu01 Polyclonal Antibody to Rhodopsin (RHO) WB; IHC; ICC; IP.
MAC777Hu21 Monoclonal Antibody to Rhodopsin (RHO) WB; IHC; ICC; IP.
Assay Kits SEC777Hu ELISA Kit for Rhodopsin (RHO) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC777Mu01 Recombinant Rhodopsin (RHO) Positive Control; Immunogen; SDS-PAGE; WB.
RPC777Mu02 Recombinant Rhodopsin (RHO) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC777Mu01 Polyclonal Antibody to Rhodopsin (RHO) WB; IHC; ICC; IP.
PAC777Mu02 Polyclonal Antibody to Rhodopsin (RHO) WB; IHC; ICC; IP.
Assay Kits SEC777Mu ELISA Kit for Rhodopsin (RHO) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Rhodopsin (RHO) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Rhodopsin (RHO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Rhodopsin (RHO) Polyclonal Antibody Customized Service Offer
Assay Kits SEC777Ra ELISA Kit for Rhodopsin (RHO) Enzyme-linked immunosorbent assay for Antigen Detection.
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  7. "A point mutation of the rhodopsin gene in one form of retinitis pigmentosa."Nature 343:364-366(1990) [PubMed] [Europe PMC] [Abstract]
  8. "Mutations within the rhodopsin gene in patients with autosomal dominant retinitis pigmentosa."N. Engl. J. Med. 323:1302-1307(1990) [PubMed] [Europe PMC] [Abstract]
  9. "A 3-bp deletion in the rhodopsin gene in a family with autosomal dominant retinitis pigmentosa."Am. J. Hum. Genet. 48:26-30(1991) [PubMed] [Europe PMC] [Abstract]
  10. "Identification of novel rhodopsin mutations associated with retinitis pigmentosa by GC-clamped denaturing gradient gel electrophoresis."Am. J. Hum. Genet. 49:699-706(1991) [PubMed] [Europe PMC] [Abstract]
  11. "Pro-347-Arg mutation of the rhodopsin gene in autosomal dominant retinitis pigmentosa."Genomics 11:468-470(1991) [PubMed] [Europe PMC] [Abstract]
  12. "Rhodopsin mutations in autosomal dominant retinitis pigmentosa."Proc. Natl. Acad. Sci. U.S.A. 88:6481-6485(1991) [PubMed] [Europe PMC] [Abstract]
  13. "Mutation spectrum of the rhodopsin gene among patients with autosomal dominant retinitis pigmentosa."Proc. Natl. Acad. Sci. U.S.A. 88:9370-9374(1991) [PubMed] [Europe PMC] [Abstract]
  14. "Autosomal dominant retinitis pigmentosa: a novel mutation in the rhodopsin gene in the original 3q linked family."Hum. Mol. Genet. 1:769-771(1992) [PubMed] [Europe PMC] [Abstract]
  15. "Point mutations of rhodopsin gene found in Japanese families with autosomal dominant retinitis pigmentosa (ADRP)."Jpn. J. Hum. Genet. 37:125-132(1992) [PubMed] [Europe PMC] [Abstract]
  16. "Identification of novel rhodopsin mutations responsible for retinitis pigmentosa: implications for the structure and function of rhodopsin."Am. J. Hum. Genet. 53:80-89(1993) [PubMed] [Europe PMC] [Abstract]
  17. "Autosomal dominant 'sector' retinitis pigmentosa due to a point mutation predicting an Asn-15-Ser substitution of rhodopsin."Hum. Mol. Genet. 2:813-814(1993) [PubMed] [Europe PMC] [Abstract]
  18. "Heterozygous missense mutation in the rhodopsin gene as a cause of congenital stationary night blindness."Nat. Genet. 4:280-283(1993) [PubMed] [Europe PMC] [Abstract]
  19. "Further screening of the rhodopsin gene in patients with autosomal dominant retinitis pigmentosa."Genomics 21:461-463(1994) [PubMed] [Europe PMC] [Abstract]
  20. "Identification of a novel rhodopsin mutation (Met-44-Thr) in a simplex case of retinitis pigmentosa."Hum. Genet. 94:283-286(1994) [PubMed] [Europe PMC] [Abstract]
  21. "Three novel rhodopsin mutations (C110F, L131P, A164V) in patients with autosomal dominant retinitis pigmentosa."Hum. Mol. Genet. 3:1203-1203(1994) [PubMed] [Europe PMC] [Abstract]
  22. "Identification of a new mutation at codon 171 of rhodopsin gene causing autosomal dominant retinitis pigmentosa."Hum. Mol. Genet. 3:1421-1421(1994) [PubMed] [Europe PMC] [Abstract]
  23. "Five novel missense mutations of the rhodopsin gene in autosomal dominant retinitis pigmentosa."Hum. Mol. Genet. 3:1433-1434(1994) [PubMed] [Europe PMC] [Abstract]
  24. "Two new rhodopsin transversion mutations (L40R; M216K) in families with autosomal dominant retinitis pigmentosa."Hum. Mutat. 3:409-410(1994) [PubMed] [Europe PMC] [Abstract]
  25. "Autosomal dominant retinitis pigmentosa in a large family: a clinical and molecular genetic study."Invest. Ophthalmol. Vis. Sci. 35:3134-3144(1994) [PubMed] [Europe PMC] [Abstract]
  26. "Missense rhodopsin mutation in a family with recessive RP."Nat. Genet. 8:10-11(1994) [PubMed] [Europe PMC] [Abstract]
  27. "Rhodopsin mutation proline347-to-alanine in a family with autosomal dominant retinitis pigmentosa indicates an important role for proline at position 347."Hum. Mol. Genet. 4:775-776(1995) [PubMed] [Europe PMC] [Abstract]
  28. "Dark-light: model for nightblindness from the human rhodopsin Gly-90-->Asp mutation."Proc. Natl. Acad. Sci. U.S.A. 92:880-884(1995) [PubMed] [Europe PMC] [Abstract]
  29. "Retinitis punctata albescens associated with the Arg135Trp mutation in the rhodopsin gene."Am. J. Ophthalmol. 121:19-25(1996) [PubMed] [Europe PMC] [Abstract]
  30. "Rhodopsin mutation G109R in a family with autosomal dominant retinitis pigmentosa."Hum. Mutat. Suppl. 1:S40-S41(1998) [PubMed] [Europe PMC] [Abstract]
  31. "A novel mutation within the rhodopsin gene (Thr-94-Ile) causing autosomal dominant congenital stationary night blindness."Hum. Mutat. 13:75-81(1999) [PubMed] [Europe PMC] [Abstract]
  32. "A dual role for EDEM1 in the processing of rod opsin."J. Cell Sci. 122:4465-4472(2009) [PubMed] [Europe PMC] [Abstract]
  33. "A homozygous p.Glu150Lys mutation in the opsin gene of two Pakistani families with autosomal recessive retinitis pigmentosa."Mol. Vis. 15:2526-2534(2009) [PubMed] [Europe PMC] [Abstract]
  34. "Next-generation genetic testing for retinitis pigmentosa." Hum. Mutat. 33:963-972(2012) [PubMed] [Europe PMC] [Abstract]