Thromboxane Receptor (TP)

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TBXA2R; TXA2-R; Thromboxane A2 Receptor; Prostanoid TP receptor

Thromboxane Receptor (TP)
The TP) is a protein on the surface of cells in the endothelium of blood vessels and in the placenta which interacts with the eicosanoid lipid thromboxane. It is a G-protein coupled receptors coupled to the G protein Gq.The gene responsible for the thromboxane receptor, TBXA2R is found on chromosome 19 and spans 15 kilobases.
Thromboxane is a potent stimulator for platelet aggregation and clot formation and also plays a role in vascular tone. The thromboxane receptor is a member of the family of G protein-coupled receptors. Mutation of the receptor can lead to a bleeding disorder.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPC822Hu01Recombinant Thromboxane Receptor (TP)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAC822Hu01Polyclonal Antibody to Thromboxane Receptor (TP)WB, ICC, IHC-P, IHC-F, ELISA
MAC822Hu22Monoclonal Antibody to Thromboxane Receptor (TP)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEC822HuELISA Kit for Thromboxane Receptor (TP)Enzyme-linked immunosorbent assay

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Thromboxane Receptor (TP)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Thromboxane Receptor (TP)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Thromboxane Receptor (TP)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Thromboxane Receptor (TP)CLIA Kit Customized Service Offer
n/aELISA Kit for Thromboxane Receptor (TP)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Thromboxane Receptor (TP)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Thromboxane Receptor (TP)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Thromboxane Receptor (TP)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Thromboxane Receptor (TP)CLIA Kit Customized Service Offer
n/aELISA Kit for Thromboxane Receptor (TP)ELISA Kit Customized Service Offer
  1. "Cloning and expression of cDNA for a human thromboxane A2 receptor."Nature 349:617-620(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization and chromosomal mapping of the human thromboxane A2 receptor gene."J. Biol. Chem. 268:25253-25259(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Alternative splicing produces a divergent cytoplasmic tail in the human endothelial thromboxane A2 receptor."J. Biol. Chem. 269:19256-19261(1994) [PubMed] [Europe PMC] [Abstract]
  4. ErratumJ. Biol. Chem. 270:7011-7011(1995) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning and pharmacologic characterization of a thromboxane A2 receptor from K562 (human chronic myelogenous leukemia) cells."J. Pharmacol. Exp. Ther. 271:1034-1041(1994) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
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  9. "Point mutation in the seventh hydrophobic domain of the human thromboxane A2 receptor allows discrimination between agonist and antagonist binding sites."Mol. Pharmacol. 44:934-939(1993) [PubMed] [Europe PMC] [Abstract]
  10. "Low expression of cell-surface thromboxane A2 receptor beta-isoform through the negative regulation of its membrane traffic by proteasomes."Prostaglandins Other Lipid Mediat. 83:237-249(2007) [PubMed] [Europe PMC] [Abstract]
  11. "RACK1 regulates the cell surface expression of the G protein-coupled receptor for thromboxane A(2)."Traffic 9:394-407(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Thromboxane A2-induced signal transduction is negatively regulated by KIAA1005 that directly interacts with thromboxane A2 receptor."Prostaglandins Other Lipid Mediat. 89:8-15(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder."J. Clin. Invest. 94:1662-1667(1994) [PubMed] [Europe PMC] [Abstract]