Fibroblast Growth Factor 3 (FGF3)

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HBGF3; INT2; Heparin-binding growth factor 3; Murine Mammary Tumor Virus Integration Site(v-int-2)Oncogene Homolog; INT-2 Proto-Oncogene Protein; Proto-oncogene Int-2

Fibroblast Growth Factor 3 (FGF3)
FGF3 is a member of the fibroblast growth factor family. FGF3 binds to Fibroblast Growth Factor Receptor 3 (FGFR3) to serve as a negative regulator of bone growth during ossification. Effectively, FGF-3 inhibits proliferation of chondrocytes within growth plate.
The FGF3 gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC906Hu01 Recombinant Fibroblast Growth Factor 3 (FGF3) Positive Control; Immunogen; SDS-PAGE; WB.
APC906Hu01 Active Fibroblast Growth Factor 3 (FGF3) Cell culture; Activity Assays.
Antibodies PAC906Hu01 Polyclonal Antibody to Fibroblast Growth Factor 3 (FGF3) WB; IHC; ICC; IP.
MAC906Hu22 Monoclonal Antibody to Fibroblast Growth Factor 3 (FGF3) WB; IHC; ICC; IP.
LAC906Hu71 Biotin-Linked Polyclonal Antibody to Fibroblast Growth Factor 3 (FGF3) WB; IHC; ICC.
Assay Kits SEC906Hu ELISA Kit for Fibroblast Growth Factor 3 (FGF3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC906Hu CLIA Kit for Fibroblast Growth Factor 3 (FGF3) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC906Mu01 Recombinant Fibroblast Growth Factor 3 (FGF3) Positive Control; Immunogen; SDS-PAGE; WB.
RPC906Mu02 Recombinant Fibroblast Growth Factor 3 (FGF3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC906Mu01 Polyclonal Antibody to Fibroblast Growth Factor 3 (FGF3) WB; IHC; ICC; IP.
PAC906Mu02 Polyclonal Antibody to Fibroblast Growth Factor 3 (FGF3) WB; IHC; ICC; IP.
Assay Kits SEC906Mu ELISA Kit for Fibroblast Growth Factor 3 (FGF3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC906Mu CLIA Kit for Fibroblast Growth Factor 3 (FGF3) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC906Ra01 Recombinant Fibroblast Growth Factor 3 (FGF3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC906Ra01 Polyclonal Antibody to Fibroblast Growth Factor 3 (FGF3) WB; IHC; ICC; IP.
MAC906Ra21 Monoclonal Antibody to Fibroblast Growth Factor 3 (FGF3) WB; IHC; ICC; IP.
Assay Kits SEC906Ra ELISA Kit for Fibroblast Growth Factor 3 (FGF3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCC906Ra CLIA Kit for Fibroblast Growth Factor 3 (FGF3) Chemiluminescent immunoassay for Antigen Detection.
  1. "Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells."Oncogene 4:429-436(1989) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Receptor specificity of the fibroblast growth factor family."J. Biol. Chem. 271:15292-15297(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Fibroblast growth factor signalling: from development to cancer."Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
  5. "Homozygous mutations in fibroblast growth factor 3 are associated with a new form of syndromic deafness characterized by inner ear agenesis, microtia, and microdontia."Am. J. Hum. Genet. 80:338-344(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Homozygous FGF3 mutations result in congenital deafness with inner ear agenesis, microtia, and microdontia."Clin. Genet. 73:554-565(2008) [PubMed] [Europe PMC] [Abstract]