Fibroblast Growth Factor 3 (FGF3)

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HBGF3; INT2; Heparin-binding growth factor 3; Murine Mammary Tumor Virus Integration Site(v-int-2)Oncogene Homolog; INT-2 Proto-Oncogene Protein; Proto-oncogene Int-2

Fibroblast Growth Factor 3 (FGF3)
FGF3 is a member of the fibroblast growth factor family. FGF3 binds to Fibroblast Growth Factor Receptor 3 (FGFR3) to serve as a negative regulator of bone growth during ossification. Effectively, FGF-3 inhibits proliferation of chondrocytes within growth plate.
The FGF3 gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPC906Hu01Recombinant Fibroblast Growth Factor 3 (FGF3)SDS-PAGE; WB; ELISA; IP.
APC906Hu01Active Fibroblast Growth Factor 3 (FGF3)Cell culture; Activity Assays; In vivo assays.
AntibodiesPAC906Hu01Polyclonal Antibody to Fibroblast Growth Factor 3 (FGF3)WB, ICC, IHC-P, IHC-F, ELISA
MAC906Hu22Monoclonal Antibody to Fibroblast Growth Factor 3 (FGF3)WB, ICC, IHC-P, IHC-F, ELISA
LAC906Hu71Biotin-Linked Polyclonal Antibody to Fibroblast Growth Factor 3 (FGF3)IHC;WB;ELISA
Assay KitsSEC906HuELISA Kit for Fibroblast Growth Factor 3 (FGF3)Enzyme-linked immunosorbent assay for Antigen Detection
SCC906HuCLIA Kit for Fibroblast Growth Factor 3 (FGF3)Chemiluminescent immunoassay for Antigen Detection

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPC906Mu01Recombinant Fibroblast Growth Factor 3 (FGF3)SDS-PAGE; WB; ELISA; IP.
RPC906Mu02Recombinant Fibroblast Growth Factor 3 (FGF3)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAC906Mu01Polyclonal Antibody to Fibroblast Growth Factor 3 (FGF3)WB, ICC, IHC-P, IHC-F, ELISA
PAC906Mu02Polyclonal Antibody to Fibroblast Growth Factor 3 (FGF3)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEC906MuELISA Kit for Fibroblast Growth Factor 3 (FGF3)Enzyme-linked immunosorbent assay for Antigen Detection
SCC906MuCLIA Kit for Fibroblast Growth Factor 3 (FGF3)Chemiluminescent immunoassay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPC906Ra01Recombinant Fibroblast Growth Factor 3 (FGF3)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAC906Ra01Polyclonal Antibody to Fibroblast Growth Factor 3 (FGF3)WB, ICC, IHC-P, IHC-F, ELISA
MAC906Ra21Monoclonal Antibody to Fibroblast Growth Factor 3 (FGF3)WB, ICC, IHC-P, IHC-F, ELISA
Assay KitsSEC906RaELISA Kit for Fibroblast Growth Factor 3 (FGF3)Enzyme-linked immunosorbent assay for Antigen Detection
SCC906RaCLIA Kit for Fibroblast Growth Factor 3 (FGF3)Chemiluminescent immunoassay for Antigen Detection
  1. "Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells."Oncogene 4:429-436(1989) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Receptor specificity of the fibroblast growth factor family."J. Biol. Chem. 271:15292-15297(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Fibroblast growth factor signalling: from development to cancer."Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
  5. "Homozygous mutations in fibroblast growth factor 3 are associated with a new form of syndromic deafness characterized by inner ear agenesis, microtia, and microdontia."Am. J. Hum. Genet. 80:338-344(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Homozygous FGF3 mutations result in congenital deafness with inner ear agenesis, microtia, and microdontia."Clin. Genet. 73:554-565(2008) [PubMed] [Europe PMC] [Abstract]