Calcium/Calmodulin Dependent Protein Kinase I (CAMK1)

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CAMKI; CaM kinase I alpha

Calcium/Calmodulin Dependent Protein Kinase I (CAMK1)
Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. CAMK1 protein truncated at residue 306 was unable to bind calcium/calmodulin and lacked kinase activity, whereas a CAMK1 protein truncated at residue 294 also did not bind calcium/calmodulin but retained kinase activity even in the absence of calcium/calmodulin. These results were consistent with essential portions of the autoinhibitory and calcium/calmodulin-binding domains encompassing residues 295 to 306 and residues C-terminal to 306, respectively. By mutation analysis, the authors showed that CAMK1 requires thr177 for its phosphorylation. Furthermore, they found that CAMK1 activity is enhanced by CAMK1 kinase in the presence of calcium/calmodulin.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPD041Hu01Recombinant Calcium/Calmodulin Dependent Protein Kinase I (CAMK1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAD041Hu01Polyclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase I (CAMK1)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Calcium/Calmodulin Dependent Protein Kinase I (CAMK1)CLIA Kit Customized Service Offer
n/aELISA Kit for Calcium/Calmodulin Dependent Protein Kinase I (CAMK1)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Calcium/Calmodulin Dependent Protein Kinase I (CAMK1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase I (CAMK1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase I (CAMK1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Calcium/Calmodulin Dependent Protein Kinase I (CAMK1)CLIA Kit Customized Service Offer
n/aELISA Kit for Calcium/Calmodulin Dependent Protein Kinase I (CAMK1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
Proteinsn/aRecombinant Calcium/Calmodulin Dependent Protein Kinase I (CAMK1)Recombinant Protein Customized Service Offer
Antibodiesn/aMonoclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase I (CAMK1)Monoclonal Antibody Customized Service Offer
n/aPolyclonal Antibody to Calcium/Calmodulin Dependent Protein Kinase I (CAMK1)Polyclonal Antibody Customized Service Offer
Assay Kitsn/aCLIA Kit for Calcium/Calmodulin Dependent Protein Kinase I (CAMK1)CLIA Kit Customized Service Offer
n/aELISA Kit for Calcium/Calmodulin Dependent Protein Kinase I (CAMK1)ELISA Kit Customized Service Offer
  1. "Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase."EMBO J. 14:3679-3686(1995) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase."J. Biomed. Sci. 5:141-149(1998) [PubMed] [Europe PMC] [Abstract]
  5. "Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5."Proc. Natl. Acad. Sci. U.S.A. 97:14400-14405(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity."J. Biol. Chem. 276:31113-31123(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase."Endocrinology 143:3651-3657(2002) [PubMed] [Europe PMC] [Abstract]
  8. "Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I."J. Biol. Chem. 278:48570-48579(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Regulation of cyclin D1/Cdk4 complexes by calcium/calmodulin-dependent protein kinase I."J. Biol. Chem. 279:15411-15419(2004) [PubMed] [Europe PMC] [Abstract]
  10. "A calcium- and calmodulin-dependent kinase Ialpha/microtubule affinity regulating kinase 2 signaling cascade mediates calcium-dependent neurite outgrowth."J. Neurosci. 27:4413-4423(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth."Neurosci. Res. 57:86-97(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex."Neuron 57:94-107(2008) [PubMed] [Europe PMC] [Abstract]
  13. "CaMKK-CaMKI signaling pathways differentially control axon and dendrite elongation in cortical neurons."J. Neurosci. 30:2807-2809(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Structure and regulation of calcium/calmodulin-dependent protein kinases."Chem. Rev. 101:2341-2352(2001) [PubMed] [Europe PMC] [Abstract]
  15. "Calmodulin-kinases: modulators of neuronal development and plasticity."Neuron 59:914-931(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Controlling the cell cycle: the role of calcium/calmodulin-stimulated protein kinases I and II."Cell Cycle 10:631-639(2011) [PubMed] [Europe PMC] [Abstract]
  18. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  19. "Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I."Cell. Signal. 25:2047-2059(2013) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "Crystal structures of human CaMKIalpha reveal insights into the regulation mechanism of CaMKI."PLoS ONE 7:E44828-E44828(2012) [PubMed] [Europe PMC] [Abstract]
  22. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]