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Carbonic Anhydrase IX (CA9)

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CA-IX; CAIX; MN; pMW1; P54/58N; Carbonic Dehydratase; Renal cell carcinoma-associated antigen G250; RCC-Associated Protein G250; Carbonate dehydratase IX

Carbonic Anhydrase IX (CA9)
CCC D076
HGNC 1383
MGI 2447188
PubMed 22289741
RGD 1306426
UniProt Q16790
Wiki CA9
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid.
CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD076Hu01 Recombinant Carbonic Anhydrase IX (CA9) Positive Control; Immunogen; SDS-PAGE; WB.
EPD076Hu61 Eukaryotic Carbonic Anhydrase IX (CA9) Positive Control; Immunogen; SDS-PAGE; WB.
APD076Hu61 Active Carbonic Anhydrase IX (CA9) Cell culture; Activity Assays.
APD076Hu01 Active Carbonic Anhydrase IX (CA9) Cell culture; Activity Assays.
Antibodies PAD076Hu01 Polyclonal Antibody to Carbonic Anhydrase IX (CA9) WB; IHC; ICC; IP.
LAD076Hu71 Biotin-Linked Polyclonal Antibody to Carbonic Anhydrase IX (CA9) WB; IHC; ICC.
MAD076Hu21 Monoclonal Antibody to Carbonic Anhydrase IX (CA9) WB; IHC; ICC; IP.
PAD076Hu06 Polyclonal Antibody to Carbonic Anhydrase IX (CA9) WB; IHC; ICC; IP.
Assay Kits SED076Hu ELISA Kit for Carbonic Anhydrase IX (CA9) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD076Mu01 Recombinant Carbonic Anhydrase IX (CA9) Positive Control; Immunogen; SDS-PAGE; WB.
RPD076Mu02 Recombinant Carbonic Anhydrase IX (CA9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD076Mu01 Polyclonal Antibody to Carbonic Anhydrase IX (CA9) WB; IHC; ICC; IP.
LAD076Mu71 Biotin-Linked Polyclonal Antibody to Carbonic Anhydrase IX (CA9) WB; IHC; ICC.
PAD076Mu02 Polyclonal Antibody to Carbonic Anhydrase IX (CA9) WB; IHC; ICC; IP.
Assay Kits SED076Mu ELISA Kit for Carbonic Anhydrase IX (CA9) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD076Ra01 Recombinant Carbonic Anhydrase IX (CA9) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD076Ra01 Polyclonal Antibody to Carbonic Anhydrase IX (CA9) WB; IHC; ICC; IP.
MAD076Ra21 Monoclonal Antibody to Carbonic Anhydrase IX (CA9) WB; IHC; ICC; IP.
Assay Kits SED076Ra ELISA Kit for Carbonic Anhydrase IX (CA9) Enzyme-linked immunosorbent assay for Antigen Detection.
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  10. "Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I."Bioorg. Med. Chem. Lett. 17:2210-2215(2007) [PubMed] [Europe PMC] [Abstract]
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  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases."Bioorg. Med. Chem. Lett. 19:1371-1375(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors."J. Am. Chem. Soc. 131:3057-3062(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Stabilization of antibody structure upon association to a human carbonic anhydrase IX epitope studied by X-ray crystallography, microcalorimetry, and molecular dynamics simulations."Proteins 71:1275-1287(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX."Proc. Natl. Acad. Sci. U.S.A. 106:16233-16238(2009) [PubMed] [Europe PMC] [Abstract]