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Hemoglobin Beta (HBb)

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HB-B; HBD; CD113t-C; Beta Globin; Spinorphin

Hemoglobin Beta (HBb)
CCC D098
HGNC 4827
MGI 96022
PubMed 10698297
RGD 2783
UniProt P68871
Wiki HBB

Beta globin (HBB, β-globin) is a protein that, along with alpha globin (HBA), makes up the most common form of hemoglobin in adult humans. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains.

The gene is located in the β-globin locus. Expression of beta globin and the neighboring globins in the β-globin locus is controlled by single locus control region (LCR). The order of the genes in the beta-globin cluster is 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'. Mutant beta globin is responsible for the sickling of red blood cells seen in sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD098Hu01 Recombinant Hemoglobin Beta (HBb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD098Hu01 Polyclonal Antibody to Hemoglobin Beta (HBb) WB; IHC; ICC; IP.
MAD098Hu21 Monoclonal Antibody to Hemoglobin Beta (HBb) WB
Assay Kits CED098Hu ELISA Kit for Hemoglobin Beta (HBb) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD098Mu01 Recombinant Hemoglobin Beta (HBb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD098Mu01 Polyclonal Antibody to Hemoglobin Beta (HBb) WB,IHC
LAD098Mu71 Biotin-Linked Polyclonal Antibody to Hemoglobin Beta (HBb) WB; IHC; ICC.
Assay Kits n/a CLIA Kit for Hemoglobin Beta (HBb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hemoglobin Beta (HBb) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Hemoglobin Beta (HBb) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Hemoglobin Beta (HBb) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Hemoglobin Beta (HBb) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Hemoglobin Beta (HBb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hemoglobin Beta (HBb) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD098Bo01 Recombinant Hemoglobin Beta (HBb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD098Bo01 Polyclonal Antibody to Hemoglobin Beta (HBb) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Hemoglobin Beta (HBb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hemoglobin Beta (HBb) ELISA Kit Customized Service Offer

Organism species: Ovis aries; Ovine (Sheep)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD098Ov01 Recombinant Hemoglobin Beta (HBb) Positive Control; Immunogen; SDS-PAGE; WB.
NPD098Ov01 Native Hemoglobin Beta (HBb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD098Ov01 Polyclonal Antibody to Hemoglobin Beta (HBb) WB; IHC; ICC; IP.
LAD098Ov71 Biotin-Linked Polyclonal Antibody to Hemoglobin Beta (HBb) WB; IHC; ICC.
MAD098Ov21 Monoclonal Antibody to Hemoglobin Beta (HBb) WB; IHC; ICC; IP.
PAD098Ov02 Polyclonal Antibody to Hemoglobin Beta (HBb) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Hemoglobin Beta (HBb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hemoglobin Beta (HBb) ELISA Kit Customized Service Offer

Organism species: Equus caballus; Equine (Horse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD098Eq01 Recombinant Hemoglobin Beta (HBb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD098Eq01 Polyclonal Antibody to Hemoglobin Beta (HBb) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Hemoglobin Beta (HBb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hemoglobin Beta (HBb) ELISA Kit Customized Service Offer

Organism species: Chicken (Gallus)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD098Ga01 Recombinant Hemoglobin Beta (HBb) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD098Ga01 Polyclonal Antibody to Hemoglobin Beta (HBb) WB; IHC; ICC; IP.
LAD098Ga71 Biotin-Linked Polyclonal Antibody to Hemoglobin Beta (HBb) WB; IHC; ICC.
MAD098Ga21 Monoclonal Antibody to Hemoglobin Beta (HBb) WB; IHC; ICC; IP.
LAD098Ga81 FITC-Linked Polyclonal Antibody to Hemoglobin Beta (HBb) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Hemoglobin Beta (HBb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Hemoglobin Beta (HBb) ELISA Kit Customized Service Offer
  1. "Nucleotide sequence analysis of coding and noncoding regions of human beta-globin mRNA."Prog. Nucleic Acid Res. Mol. Biol. 19:165-175(1976) [PubMed] [Europe PMC] [Abstract]
  2. "The nucleotide sequence of the human beta-globin gene."Cell 21:647-651(1980) [PubMed] [Europe PMC] [Abstract]
  3. "The beta-globin recombinational hotspot reduces the effects of strong selection around HbC, a recently arisen mutation providing resistance to malaria."Am. J. Hum. Genet. 77:637-642(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The constitution of normal adult human haemoglobin."Hoppe-Seyler's Z. Physiol. Chem. 325:283-286(1961) [PubMed] [Europe PMC] [Abstract]
  7. "Gene mutations in human haemoglobin: the chemical difference between normal and sickle cell haemoglobin."Nature 180:326-328(1957) [PubMed] [Europe PMC] [Abstract]
  8. "Isolation of a hemoglobin-derived opioid peptide from cerebrospinal fluid of patients with cerebrovascular bleedings."Biochem. Biophys. Res. Commun. 184:1060-1066(1992) [PubMed] [Europe PMC] [Abstract]
  9. "Hemoglobin Hammersmith (beta 42 (CD1) Phe replaced by Ser) associated with severe hemolytic anemia."Hemoglobin 5:97-105(1981) [PubMed&l