Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1)

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A2MRAP; A2RAP; HBP44; MRAP; RAP; Alpha-2-Macroglobulin Receptor-Associated Protein 1

Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1)
LRPAP1 is involved with trafficking of certain members of the LDL receptor family including LRP1 and LRP2.The alpha-2-macroglobulin receptor complex, as purified by affinity chromatography, contains 3 polypeptides: a 515-kD heavy chain, an 85-kD light chain, and a 39-kD associated protein.The deduced amino acid sequence contains a putative signal sequence that precedes the 323-residue mature protein. The sequence showed 73% identity with a rat protein reported to be a pathogenic domain of the Heymann nephritis antigen gp330 and 77% identity to a 44-kD mouse heparin-binding protein termed HBP-44. There are also similarities between MRAP and apolipoprotein E. Studies indicated that the molecule is present on the cell surface, forming a complex with the heavy and light chains of the alpha-2-macroglobulin receptor.

Organism species: Homo sapiens (Human)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPD100Hu01Recombinant Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAD100Hu01Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1)CLIA Kit Customized Service Offer
n/aELISA Kit for Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1)ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPD100Mu01Recombinant Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1)SDS-PAGE; WB; ELISA; IP.
RPD100Mu02Recombinant Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAD100Mu01Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1)WB, ICC, IHC-P, IHC-F, ELISA
PAD100Mu02Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1)WB, ICC, IHC-P, IHC-F, ELISA
LAD100Mu71Biotin-Linked Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1)IHC;WB;ELISA
Assay Kitsn/aCLIA Kit for Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1)CLIA Kit Customized Service Offer
n/aELISA Kit for Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1)ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO.PRODUCT NAMEAPPLICATIONS
ProteinsRPD100Ra01Recombinant Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1)SDS-PAGE; WB; ELISA; IP.
AntibodiesPAD100Ra01Polyclonal Antibody to Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1)WB, ICC, IHC-P, IHC-F, ELISA
Assay Kitsn/aCLIA Kit for Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1)CLIA Kit Customized Service Offer
n/aELISA Kit for Low Density Lipoprotein Receptor Related Protein Associated Protein 1 (LRPAP1)ELISA Kit Customized Service Offer
  1. "Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen."J. Biol. Chem. 266:13364-13369(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Analysis of the human LRPAP1 gene coding for the lipoprotein receptor-associated protein: identification of 22 polymorphisms and one mutation."Genomics 52:145-151(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning, characterization, and chromosomal localization to 4p16 of the human gene (LRPAP1) coding for the alpha 2-macroglobulin receptor-associated protein and structural comparison with the murine gene coding for the 44-kDa heparin-binding protein."Genomics 25:492-500(1995) [PubMed] [Europe PMC] [Abstract]
  6. "The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330."J. Biol. Chem. 267:21162-21166(1992) [PubMed] [Europe PMC] [Abstract]
  7. "39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein."EMBO J. 14:2269-2280(1995) [PubMed] [Europe PMC] [Abstract]
  8. "The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein."J. Biol. Chem. 276:28889-28896(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Mutations in LRPAP1 are associated with severe myopia in humans."Am. J. Hum. Genet. 93:313-320(2013) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "The solution structure of the N-terminal domain of alpha2-macroglobulin receptor-associated protein."Proc. Natl. Acad. Sci. U.S.A. 94:7521-7525(1997) [PubMed] [Europe PMC] [Abstract]
  14. "1H, 13C and 15N resonance assignments of domain 1 of receptor associated protein."J. Biomol. NMR 26:187-188(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Binding site structure of one LRP-RAP complex: implications for a common ligand-receptor binding motif."J. Mol. Biol. 362:700-716(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Structure of an LDLR-RAP complex reveals a general mode for ligand recognition by lipoprotein receptors."Mol. Cell 22:277-283(2006) [PubMed] [Europe PMC] [Abstract]
  17. "RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi."Mol. Cell 22:423-430(2006) [PubMed] [Europe PMC] [Abstract]